Serum 25-hydroxyvitamin D and the risk of stroke in Hong Kong Chinese
Leung RY, Han Y, Sing CW, Cheung BM, Wong IC, Tan KC, Kung AW, Cheung CL
Thrombosis and haemostasis · 28 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Health and Medical Research Fund
- Organización sin fines de lucro
- HMRF
- Subvenciones
- Health and Medical Research Fund (HKU12132451)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2016-10-27 · Thromb Haemost · vol. 117 · número 01 · págs. 158–163
- Editorial
- Thieme Medical Publishers (Germany)
- Citado
- 36 citas · más que el 93% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Vitamin C and Antioxidants Research
- Palabras clave
- Stroke (engine), Medicine, Internal medicine, Cardiology
- MeSH
- humans, brain ischemia, vitamin d deficiency, vitamin d, prognosis, multivariate analysis, proportional hazards models, risk assessment, risk factors, chi-square distribution, prospective studies, aged, middle aged, hong kong, female, male, stroke, electronic health records, biomarkers, asian people
8 autores
- Chor‐Wing Sing🇭🇰Chinese University of Hong Kong; University of Hong Kong
- Bernard M.Y. Cheung🇭🇰Chinese University of Hong Kong; University of Hong Kong
- Ian Chi Kei Wong🇭🇰🇬🇧Chinese University of Hong Kong; University College London; University of Hong Kong
- K. C. B. Tan🇭🇰Chinese University of Hong Kong; University of Hong Kong
- Annie W.C. Kung🇭🇰Chinese University of Hong Kong; University of Hong Kong
- Raymond Y.H. Leung
- Yi Han
- Ching‐Lung Cheung🇭🇰HKU-Pasteur Research Pole; University of Hong Kong
Resumen
El texto original del estudio, en el idioma en que se publicó.
Low vitamin D levels have been associated with various cardiovascular diseases; however, whether it is associated with stroke remains inconclusive. We aimed to evaluate the association between serum 25-hydroxyvitamin D and risk of stroke. We conducted a cohort study consisting of 3,458 participants from the Hong Kong Osteoporosis Study aged ≥45 at baseline, examined between 1995 and 2010 and followed up using electronic medical records. Ischaemic and haemorrhagic stroke were defined using the ICD-9 code. In multivariable Cox-proportional hazard regression, quintiles 1 and 4 were significantly associated with increased risk of stroke when compared to the highest quintile (Quintile 1: HR, 1.78; 95 % CI, 1.16-2.74 and quintile 4: HR, 1.61; 95 % CI, 1.07-2.43). A similar association was observed in both men and women. In subgroup analysis, the association was specifically observed for ischaemic stroke, but not haemorrhagic stroke. Using a penalized regression spline, the association between vitamin D and risk of stroke was in a reverse J-shape, with the lowest risk of stroke being observed at 25(OH)D levels between 70 and 80 nmol/l. In conclusion, a low vitamin D level is associated with increased risk of ischaemic stroke; however, whether high vitamin D level is also associated with increased risk of stroke requires further study.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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