Financiado en parte por Bupa Foundation
Determinants of the Maternal 25-Hydroxyvitamin D Response to Vitamin D Supplementation During Pregnancy
Moon RJ, Harvey NC, Cooper C, D'Angelo S, Crozier SR, Inskip HM, Schoenmakers I, Prentice A, Arden NK, Bishop NJ, Carr A, Dennison EM, Eastell R, Fraser R, Gandhi SV, Godfrey KM, Kennedy S, Mughal MZ, Papageorghiou AT, Reid DM, Robinson SM, Javaid MK
The Journal of clinical endocrinology and metabolism · 37 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- National Institute for Health and Care Research
- Empresa
- Bupa Foundation
- Gobierno
- European Commission
- Organización sin fines de lucro
- Versus Arthritis
- Gobierno
- Medical Research Council
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- National Institute for Health and Care Research (10/33/04); Medical Research Council (MR/K006312/1); National Institute for Health and Care Research (HTA/10/33/04); National Institute for Health and Care Research (NF-SI-0515-10042); Medical Research Council (MC_UU_12011/4); Versus Arthritis (21231); National Institute for Health and Care Research (NF-SI-0508-10082); Versus Arthritis (19583); Versus Arthritis (17702); Medical Research Council (MC_UU_12011/2); Medical Research Council (MC_UU_12011/1); National Institute for Health and Care Research (NF-SI-0513-10085)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2016-10-27 · J Clin Endocrinol Metab · vol. 101 · número 12 · págs. 5012–5020
- Editorial
- Oxford University Press
- Citado
- 49 citas · más que el 96% de estudios similares · 5.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Gestational Diabetes Research and Management · Per- and polyfluoroalkyl substances research
- Palabras clave
- Pregnancy, Vitamin D and neurology, Medicine, Vitamin, vitamin D deficiency, Internal medicine, Endocrinology, Biology, Genetics
- MeSH
- humans, weight gain, cholecalciferol, vitamins, vitamin d, double-blind method, seasons, pregnancy, pregnancy trimesters, adult, female, young adult, outcome assessment, health care
22 autores
- Rebecca Jane Moon🇬🇧Southampton General Hospital; University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Nicholas C. Harvey🇬🇧University Hospital Southampton NHS Foundation Trust; National Institute for Health and Care Research; NIHR Southampton Biomedical Research Centre; MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Cyrus Cooper🇬🇧 · autor de correspondenciaUniversity Hospital Southampton NHS Foundation Trust; National Institute for Health and Care Research; NIHR Southampton Biomedical Research Centre; MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Stefania D’Angelo🇬🇧University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Sarah Crozier🇬🇧University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Hazel M. Inskip🇬🇧University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Inez Schoenmakers🇬🇧University of East Anglia; MRC Elsie Widdowson Laboratory; NIHR Southampton Biomedical Research Centre
- Ann Prentice🇬🇧MRC Elsie Widdowson Laboratory; NIHR Southampton Biomedical Research Centre
- Nigel Arden🇬🇧University of Oxford; NIHR Oxford Biomedical Research Centre; NIHR Southampton Biomedical Research Centre
- Nicholas J. Bishop🇬🇧NIHR Southampton Biomedical Research Centre; Sheffield Children's Hospital; University of Sheffield
- Andrew Jonathan Carr🇬🇧University of Oxford; NIHR Oxford Biomedical Research Centre; NIHR Southampton Biomedical Research Centre
- Elaine Margaret Dennison🇬🇧University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Richard Eastell🇬🇧NIHR Southampton Biomedical Research Centre; University of Sheffield
- Robert B. Fraser🇬🇧NIHR Southampton Biomedical Research Centre; University of Sheffield
- Saurabh V. Gandhi🇬🇧NIHR Southampton Biomedical Research Centre; University of Sheffield
- Keith M. Godfrey🇬🇧University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Stephen Kennedy🇬🇧John Radcliffe Hospital; University of Oxford; NIHR Southampton Biomedical Research Centre
- Zulf Mughal🇬🇧NIHR Southampton Biomedical Research Centre; Royal Manchester Children's Hospital
- Aris T. Papageorghiou🇬🇧John Radcliffe Hospital; University of Oxford; NIHR Southampton Biomedical Research Centre
- David M. Reid🇬🇧University of Aberdeen; NIHR Southampton Biomedical Research Centre
- Sian M. Robinson🇬🇧University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- M K Javaid🇬🇧University of Oxford; NIHR Oxford Biomedical Research Centre; NIHR Southampton Biomedical Research Centre
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Current approaches to antenatal vitamin D supplementation do not account for interindividual differences in 25-hydroxyvitamin D (25(OH)D) response.
Objective
We assessed which maternal and environmental characteristics were associated with 25(OH)D after supplementation with cholecalciferol.
Design
Within-randomization-group analysis of participants in the Maternal Vitamin D Osteoporosis Study trial of vitamin D supplementation in pregnancy.
Setting
Hospital antenatal clinics.
Participants
A total of 829 pregnant women (422 placebo, 407 cholecalciferol). At 14 and 34 weeks of gestation, maternal anthropometry, health, and lifestyle were assessed and 25(OH)D measured. Compliance was determined using pill counts at 19 and 34 weeks.
Interventions
1000 IU/d of cholecalciferol or matched placebo from 14 weeks of gestation until delivery.
Main outcome measure
25(OH)D at 34 weeks, measured in a single batch (Diasorin Liaison).
Results
25(OH)D at 34 weeks of gestation was higher in the women randomized to vitamin D (mean [SD], 67.7 [21.3] nmol/L) compared with placebo (43.1 [22.5] nmol/L; P < .001). In women randomized to cholecalciferol, higher pregnancy weight gain from 14 to 34 weeks of gestation (kg) (β = -0.81 [95% confidence interval -1.39, -0.22]), lower compliance with study medication (%) (β = -0.28 [-0.072, -0.48]), lower early pregnancy 25(OH)D (nmol/L) (β = 0.28 [0.16, 0.40]), and delivery in the winter vs the summer (β = -10.5 [-6.4, -14.6]) were independently associated with lower 25(OH)D at 34 weeks of gestation.
Conclusions
Women who gained more weight during pregnancy had lower 25(OH)D in early pregnancy and delivered in winter achieved a lower 25(OH)D in late pregnancy when supplemented with 1000 IU/d cholecalciferol. Future studies should aim to determine appropriate doses to enable consistent repletion of 25(OH)D during pregnancy.
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