Financiado en parte por Cereal Partners Worldwide
A Whole-Grain Diet Reduces Cardiovascular Risk Factors in Overweight and Obese Adults: A Randomized Controlled Trial
Kirwan JP, Malin SK, Scelsi AR, Kullman EL, Navaneethan SD, Pagadala MR, Haus JM, Filion J, Godin JP, Kochhar S, Ross AB
The Journal of nutrition · 82 citas
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Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- National Institutes of Health
- Empresa
- Cereal Partners Worldwide
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Research Resources
- Subvenciones
- National Center for Research Resources (UL1RR024989); National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007319)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2016-10-20 · J Nutr · vol. 146 · número 11 · págs. 2244–2251
- Editorial
- Elsevier BV
- Citado
- 114 citas · más que el 99% de estudios similares · 11.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 66 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- whole grains, refined grains, cardiovascular risk factors, hypertension, overweight, obesity, body composition, adiponectin, serum lipids, LDL cholesterol, total cholesterol, inflammation, glycemia, older adults, dietary intervention
- MeSH
- humans, cardiovascular diseases, insulin resistance, blood glucose, lipids, diet, risk factors, double-blind method, body composition, blood pressure, adult, middle aged, female, male, overweight, whole grains
11 autores
- John P. Kirwan🇺🇸 · autor de correspondenciaCleveland Clinic
- Steven K. Malin🇺🇸Cleveland Clinic; Cleveland Clinic Lerner College of Medicine
- Amanda R. Scelsi🇺🇸Cleveland Clinic; Cleveland Clinic Lerner College of Medicine
- Emily L. Kullman🇺🇸Cleveland Clinic; Cleveland Clinic Lerner College of Medicine
- Sankar Dass Navaneethan🇺🇸Cleveland Clinic
- Mangesh R. Pagadala🇺🇸Cleveland Clinic
- Jacob M. Haus🇺🇸Cleveland Clinic; Cleveland Clinic Lerner College of Medicine
- Julianne Filion🇺🇸Cleveland Clinic; Cleveland Clinic Lerner College of Medicine
- Jean‐Philippe Godin🇨🇭Nestlé (Switzerland)
- Sunil Kochhar🇨🇭Nestlé (Switzerland)
- Alastair B. Ross🇨🇭🇸🇪Nestlé (Switzerland); Chalmers University of Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Increased dietary whole-grain intake may protect against cardiovascular disease (CVD).
Objective
The objective was to evaluate the efficacy of whole grains compared with refined grains on body composition, hypertension, and related mediators of CVD in overweight and obese adults.
Methods
We conducted a double-blind, randomized, controlled crossover trial in 40 overweight or obese men and women aged <50 y with no known history of CVD. Complete whole-grain and refined-grain diets were provided for two 8-wk periods, with a 10-wk washout between diets. Macronutrient composition was matched, except for the inclusion of either whole grains or refined grains (50 g/1000 kcal in each diet). Measurements included blood pressure, body composition, blood lipids and adiponectin, and markers of inflammation and glycemia.
Results
Thirty-three participants (6 men and 27 women) completed the trial [mean ± SD age: 39 ± 7 y; mean ± SD body mass index (in kg/m2): 33.1 ± 4.3]. Decreases in diastolic blood pressure were -5.8 mm Hg (95% CI: -7.7, -4.0 mm Hg) after the whole-grain diet and -1.6 mm Hg (95% CI: -4.4, 1.3 mm Hg) after the control diet (between effect, P = 0.01). Decreases in plasma adiponectin were -0.1 (95% CI: -0.9, 0.7) after the whole-grain diet and -1.4 (95% CI: -2.6, -0.3) after the control diet (between effect, P = 0.05). Decreases in diastolic blood pressure correlated with the circulating adiponectin concentration (r = 0.35, P = 0.04). Substantial reductions in body weight, fat loss, systolic blood pressure, total cholesterol, and LDL cholesterol were observed during both diet periods, with no relevant difference between them.
Conclusions
The improvement in diastolic blood pressure was >3-fold greater in overweight and obese adults when they consumed a whole-grain compared with a refined-grain diet. Because diastolic blood pressure predicts mortality in adults aged <50 y, increased whole-grain intake may provide a functional approach to control hypertension. This may benefit patients at risk of vascular-related morbidity and mortality. This trial was registered at clinicaltrials.gov as NCT01411540.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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