Urinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches
Zhu Y, Wang P, Sha W, Sang S
Scientific reports · 37 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Biomarcadores de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Agriculture
- Gobierno
- National Institute of Food and Agriculture
- Subvenciones
- National Institute of Food and Agriculture (2012-38821-20012)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-11-02 · Sci Rep · vol. 6 · número 1 · pág. 36278
- Editorial
- Nature Portfolio
- Citado
- 50 citas · más que el 86% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 92 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Metabolomics and Mass Spectrometry Studies · Nutritional Studies and Diet · Nutrition, Genetics, and Disease
- Palabras clave
- Metabolomics, Biomarker, Endogeny, Whole grains, Medicine, Disease, Biomarker discovery, Biotechnology, Bioinformatics, Physiology, Biology, Internal medicine, Food science, Biochemistry, Proteomics, Gene
- MeSH
- humans, triticum, neoplasms, cardiovascular diseases, chronic disease, resorcinols, benzoxazines, diet, metabolomics, hydroxybenzoates, biomarkers, whole grains
4 autores
- Yingdong Zhu🇺🇸North Carolina Agricultural and Technical State University
- Pei Wang🇺🇸North Carolina Agricultural and Technical State University
- Wei Sha🇺🇸University of North Carolina at Charlotte
- Shengmin Sang🇺🇸North Carolina Agricultural and Technical State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Mounting evidence suggests that whole grain (WG) intake plays an important role in chronic disease prevention. However, numerous human studies have failed to produce clear-cut conclusions on this topic. Here, a combination of non-targeted and targeted metabolomics approaches, together with kinetic studies, was used to investigate biomarkers of WG wheat intake and further explore the diet-disease associations. Via these integrated approaches, forty-one compounds were identified as the most discriminating endogenous metabolites after WG versus refined grain (RG) wheat bread consumption. The corresponding biological assessment of these endogenous changes suggests that, in contrast to RG consumption, WG wheat consumption may facilitate antioxidant defense systems and moderate the risk factors of cancer, cardiovascular diseases, and other chronic diseases. A panel of urinary markers consisting of seven alkylresorcinol metabolites and five benzoxazinoid derivatives as specific biomarkers, as well as five phenolic acid derivatives, was also established to cover multiple time points and longer time periods for correctly and objectively monitoring WG wheat intake. Through these findings, we have established a comprehensive biomarker pool to better assess WG wheat consumption, and to monitor the endogenous changes that are linked to health effects of WG wheat consumption.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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