Differential Effects of Red Meat/Refined Grain Diet and Dairy/Chicken/Nuts/Whole Grain Diet on Glucose, Insulin and Triglyceride in a Randomized Crossover Study
Kim Y, Keogh JB, Clifton PM
Nutrients · 25 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-10-30 · Nutrients · vol. 8 · número 11 · pág. 687
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 35 citas · más que el 91% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Meat and Animal Product Quality · Agriculture Sustainability and Environmental Impact
- Palabras clave
- Postprandial, Crossover study, Meal, Glycemic index, Area under the curve, Insulin, Glycemic, Triglyceride, Type 2 diabetes, Medicine, Food science, Animal science, Diabetes mellitus, Internal medicine, Biology, Endocrinology, Placebo, Cholesterol
- MeSH
- animals, chickens, sus scrofa, humans, nuts, diabetes mellitus, type 2, glucose intolerance, hyperinsulinism, hypertriglyceridemia, risk, cross-over studies, food handling, bread, dairy products, dietary fiber, meat, adult, middle aged, patient dropouts, south australia, male, diet, western, diet, healthy
3 autores
- Yoona Kim🇦🇺University of South Australia
- Jennifer B Keogh🇦🇺University of South Australia
- Peter Marshall Clifton🇦🇺 · autor de correspondenciaUniversity of South Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Epidemiological studies suggest that a diet high in processed meat, with a high glycemic index is associated with an increased risk of type 2 diabetes. It is not clear if this is due to altered insulin sensitivity or an enhanced postprandial glucose. We aimed to compare the acute metabolic response of two different types of meals after ingestion of the matching diet for four weeks. The study was a randomized, crossover acute meal study. Volunteers consumed either a red meat/refined grain meal or a dairy/chicken/nuts/wholegrain meal after four weeks of the matching diet. After a three-week washout period and four weeks of the alternate diet, they consumed the matching meal. The diets differed with respect to both protein and carbohydrate sources. Blood samples were taken for 180 min for the measurement of glucose, insulin, C-peptide and triglyceride. Fifty-one participants (age: 35.1 ± 15.6 years; body mass index: 27.7 ± 6.9 kg/m², 17 with normal and 34 with impaired glucose tolerance) completed two meal tests. The area under the curve (p p = 0.001) for insulin was significantly higher after the red meat/refined grain diet than after the dairy/chicken/nuts/whole grain diet. There was an interaction between meal and glucose tolerance group (p < 0.05) in the area under the curve (AUC) and the incremental area under the curve (iAUC) of glucose; the red meat/refined grain diet increased glucose relative to the dairy/chicken/nuts/whole grain diet only in the normal group (+2.5 mmol/L/3 h). The red meat/refined grain diet increased glucose and insulin responses compared with the dairy/chicken/nuts/whole grain diet. This meal pattern would increase pancreatic stress long term and may account for the increased risk of type 2 diabetes with this diet.
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