High-Dose Monthly Vitamin D for Prevention of Acute Respiratory Infection in Older Long-Term Care Residents: A Randomized Clinical Trial
Ginde AA, Blatchford P, Breese K, Zarrabi L, Linnebur SA, Wallace JI, Schwartz RS
Journal of the American Geriatrics Society · 119 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Veterans Affairs
- Organización sin fines de lucro
- American Geriatrics Society
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- NIH Clinical Center
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NIA NIH HHS
- Gobierno
- NCATS NIH HHS
- Subvenciones
- National Center for Advancing Translational Sciences (UL 1 TR001082); National Institute on Aging (K23AG040708)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2016-11-16 · J Am Geriatr Soc · vol. 65 · número 3 · págs. 496–503
- Editorial
- Wiley
- Citado
- 158 citas · más que el 98% de estudios similares · 7.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Geriatric Care and Nursing Homes · Nutrition and Health Studies
- Palabras clave
- vitamin D supplementation, high-dose vitamin D, acute respiratory infections, infection control, long-term care residents, older adults, falls, fracture, 25-hydroxyvitamin D, hypercalcemia, kidney stones
- MeSH
- humans, respiratory tract infections, cholecalciferol, vitamins, vitamin d, double-blind method, accidental falls, dose-response relationship, drug, aged, 80 and over, assisted living facilities, skilled nursing facilities, colorado, female, male, fractures, bone
7 autores
- Adit A. Ginde🇺🇸 · autor de correspondenciaUniversity of Colorado Anschutz
- Patrick Jud Blatchford🇺🇸Colorado School of Public Health; VA Eastern Colorado Health Care System
- Keith Breese🇺🇸University of Colorado Anschutz
- Lida Zarrabi🇺🇸University of Colorado Anschutz
- Sunny Anne Linnebur🇺🇸University of Colorado Anschutz
- Jeffrey I. Wallace🇺🇸University of Colorado Anschutz
- Robert S. Schwartz🇺🇸VA Eastern Colorado Health Care System; University of Colorado Anschutz
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To determine the efficacy and safety of high-dose vitamin D supplementation for prevention of acute respiratory infection (ARI) in older long-term care residents.
Design
Randomized controlled trial investigating high-dose vs standard-dose vitamin D from 2010 to 2014.
Setting
Colorado long-term care facilities.
Participants
Long-term care residents aged 60 and older (n = 107).
Intervention
The high-dose group received monthly supplement of vitamin D3 100,000 IU, the standard-dose group received a monthly placebo (for participants taking 400-1,000 IU/d as part of usual care) or a monthly supplement of 12,000 IU of vitamin D3 (for participants taking <400 IU/d as part of usual care).
Measurements
The primary outcome was incidence of ARI during the 12-month intervention. Secondary outcomes were falls and fractures, 25-hydroxyvitamin D levels, hypercalcemia, and kidney stones.
Results
Participants (55 high dose, 52 standard dose) were randomized and included in the final analysis. The high-dose group had 0.67 ARIs per person-year and the standard-dose group had 1.11 (incidence rate ratio (IRR) = 0.60, 95% confidence interval (CI) = 0.38-0.94, P = .02). Falls were more common in the high-dose group (1.47 per person-year vs 0.63 in standard-dose group; IRR = 2.33, 95% CI = 1.49-3.63, P < .001). Fractures were uncommon and similar in both groups (high dose 0.10 vs standard dose 0.19 per person-year; P = .31). Mean trough 25-hydroxyvitamin D levels during the trial were 32. ng/mL in the high-dose group and 25.1 ng/mL in the standard-dose group. There was no hypercalcemia or kidney stones in either group.
Conclusion
Monthly high-dose vitamin D3 supplementation reduced the incidence of ARI in older long-term care residents but was associated with a higher rate of falls without an increase in fractures.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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