The effect of photobiomodulation on chemotherapy-induced peripheral neuropathy: A randomized, sham-controlled clinical trial
Argenta PA, Ballman KV, Geller MA, Carson LF, Ghebre R, Mullany SA, Teoh DG, Winterhoff BJ, Rivard CL, Erickson BK
Gynecologic oncology · 34 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-11-22 · Gynecol Oncol · vol. 144 · número 1 · págs. 159–166
- Editorial
- Elsevier BV
- Citado
- 57 citas · más que el 86% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cancer Treatment and Pharmacology · Chemotherapy-related skin toxicity · Pain Mechanisms and Treatments
- Palabras clave
- low-level laser therapy, chemotherapy-induced peripheral neuropathy, physiotherapy, cancer treatment side effects, multimodal therapy
- MeSH
- humans, neoplasms, peripheral nervous system diseases, antineoplastic agents, treatment outcome, severity of illness index, prospective studies, cross-over studies, double-blind method, aged, aged, 80 and over, middle aged, female, physical therapy modalities, low-level light therapy
10 autores
- Peter A. Argenta🇺🇸 · autor de correspondenciaUniversity of Minnesota
- Karla V. Ballman🇺🇸Cornell University; Weill Cornell Medicine
- Melissa Ann Geller🇺🇸University of Minnesota
- Linda F. Carson🇺🇸University of Minnesota
- Rahel G. Ghebre🇺🇸University of Minnesota
- Sally A. Mullany🇺🇸University of Minnesota
- Deanna Gek Koon Teoh🇺🇸University of Minnesota
- Boris J. N. Winterhoff🇺🇸University of Minnesota
- Colleen Lee Rivard🇺🇸University of Minnesota
- Britt Kristina Erickson🇺🇸University of Minnesota
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer therapy with few efficacious treatments.
Methods
We enrolled 70 patients with CIPN in a randomized, double-blinded, sham-controlled, cross-over trial to determine if photobiomodulation (PBM)±physiotherapy reduced the symptoms of neuropathy compared to sham treatment. At the conclusion of follow-up, sham-arm patients could cross-over into a third arm combining PBM and physiotherapy to determine if multimodal treatment had additive effects. Treatment included 30minute sessions 3-times weekly for 6weeks using either PBM or sham therapy. Neuropathy was assessed using the modified total neuropathy score (mTNS) at initiation and 4, 8, and 16weeks after initiating treatment.
Results
Sham-treated patients experienced no significant change in mTNS scores at any point during the primary analysis. PBM patients experienced significant reduction in mTNS scores at all time points. Mean changes in mTNS score (and corresponding percent drop from baseline) for sham and PBM-group patients respectively were -0.1 (-0.7%) and -4.2 (-32.4%) at 4weeks (p<0.001), 0.2 (0.0%) and -6.8 (-52.6%) at 8weeks (p<0.001), and 0.0 (0.1%) and -5.0 (-38.8%) at 16weeks (p<0.001). Patients who crossed over into the PBM/PT-group experienced similar results to those treated primarily; changes in mTNS score from baseline were -5.5 (-40.6%) 4weeks (p<0.001), -6.9 (-50.9%) at 8weeks (p<0.001), and -4.9 (-35.9%) at 16weeks (p<0.001). The addition of physiotherapy did not improve outcomes over PBM alone.
Conclusion and relevance
Among patients with CIPN, PBM produced significant reduction in neuropathy symptoms.
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