Dietary nitrate does not affect physical activity or outcomes in healthy older adults in a randomized, cross-over trial
Siervo M, Oggioni C, Jakovljevic DG, Trenell M, Mathers JC, Houghton D, Celis-Morales C, Ashor AW, Ruddock A, Ranchordas M, Klonizakis M, Williams EA
Nutrition research (New York, N.Y.) · 29 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Alzheimer's Society
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- Medical Research Council
- Gobierno
- Economic and Social Research Council
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- Economic and Social Research Council (ES/K007688/1); Medical Research Council (MR/N007921/1); Medical Research Council (MR/K006312/1); Medical Research Council (MR/L016354/1); Economic and Social Research Council (ES/K007688/1); National Institute for Health and Care Research (SRF-2011-04-017)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2016-11-14 · Nutr Res · vol. 36 · número 12 · págs. 1361–1369
- Editorial
- Elsevier BV
- Citado
- 37 citas · más que el 97% de estudios similares · 8.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Cardiovascular and exercise physiology · Exercise and Physiological Responses · Muscle metabolism and nutrition
- Palabras clave
- dietary nitrate, beetroot juice, older adults, exercise capacity, oxygen consumption, physical abilities, physical activity, nitric oxide bioavailability, aging, grip strength, walking speed, urinary nitrate
- MeSH
- humans, beta vulgaris, nitrates, nitric oxide, plant extracts, exercise test, body mass index, hand strength, exercise, diet, cross-over studies, double-blind method, age factors, oxygen consumption, aging, reference values, physical fitness, aged, middle aged, female, male, gas chromatography-mass spectrometry
12 autores
- Mario Siervo🇬🇧 · autor de correspondenciaNewcastle University
- Clio Oggioni🇬🇧Newcastle University
- Djordje G. Jakovljević🇬🇧Newcastle University
- Michael I. Trenell🇬🇧Newcastle University
- John Cummings Mathers🇬🇧Newcastle University
- David Houghton🇬🇧Newcastle University
- Carlos A. Celis-Morales🇬🇧Newcastle University
- Ammar Waham Ashor🇬🇧Newcastle University
- Alan D. Ruddock🇬🇧Sheffield Hallam University
- Mayur Krachna Ranchordas🇬🇧Sheffield Hallam University
- Markos Klonizakis🇬🇧Sheffield Hallam University
- Elizabeth A. Williams🇬🇧University of Sheffield
Resumen
El texto original del estudio, en el idioma en que se publicó.
Although dietary nitrate (NO3-) ingestion appears to enhance exercise capacity and performance in young individuals, inconclusive findings have been reported in older people. Therefore, we conducted a double-blind, crossover randomized clinical trial using beetroot juice in older healthy participants, who were classified as normal weight and overweight. We tested whether consumption of beetroot juice (a rich source of NO3-) for 1 week would increase nitric oxide bioavailability via the nonenzymatic pathway and enhance (1) exercise capacity during an incremental exercise test, (2) physical capability, and (3) free-living physical activity. Twenty nonsmoking, healthy participants between 60 and 75 years of age and with a body mass index of 20.0 to 29.9 kg/m2 were included. Presupplementation and postsupplementation resting, submaximal, maximal, and recovery gas exchanges were measured. Physical capability was measured by hand-grip strength, time-up-and-go, repeated chair rising test, and 10-m walking speed. Free-living physical activity was assessed by triaxal accelerometry. Changes in urinary and plasmaNO3-concentrations were measured by gas chromatography-mass spectrometry. Nineteen participants (male-to-female ratio, 9:10) completed the study.Beetroot juice increased significantly both plasma and urinary NO3-concentrations (P3-on muscular performance is not known, and mechanistic studies and larger trials are needed to test this hypothesis.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.