Radiological and biochemical effects (CTX-II, MMP-3, 8, and 13) of low-level laser therapy (LLLT) in chronic osteoarthritis in Al-Kharj, Saudi Arabia
S GN, Kamal W, George J, Manssor E
Lasers in medical science · 28 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Prince Sattam bin Abdulaziz University
- Subvenciones
- Prince Sattam bin Abdulaziz University (2015/01/4375)
Según 1 financiador declarado.
Publicación
- Publicado
- 2016-12-02 · Lasers Med Sci · vol. 32 · número 2 · págs. 297–303
- Editorial
- Springer Science+Business Media
- Citado
- 44 citas · más que el 96% de estudios similares · 5.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Osteoarthritis Treatment and Mechanisms · Medical and Biological Ozone Research
- Palabras clave
- low-level laser therapy, knee osteoarthritis, chronic osteoarthritis, matrix metalloproteinases, MMP-3, MMP-8, MMP-13, joint space width, analgesia, articular cartilage degeneration
- MeSH
- knee joint, animals, humans, osteoarthritis, knee, chronic disease, collagen type ii, matrix metalloproteinases, peptide fragments, placebos, pain measurement, demography, aged, middle aged, saudi arabia, female, male, low-level light therapy
4 autores
- Gopal S Nambi🇸🇦 · autor de correspondenciaPrince Sattam Bin Abdulaziz University
- Walid Kamal Abdelbasset🇸🇦Prince Sattam Bin Abdulaziz University
- Julie Saji George🇸🇦Prince Sattam Bin Abdulaziz University
- E Manssor🇸🇦Prince Sattam Bin Abdulaziz University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Inflammation of synovial membrane and degeneration of articular cartilage in osteoarthritis (OA) lead to major changes in joint space width (JSW) and biochemical components such as collagen-II telopeptide (CTX-II) and matrix metallo protineases (MMP-3, 8, and 13). Low-level laser therapy (LLLT) is thought to have an analgesic effect as well as biomodulatory effect on microcirculation and cartilage regeneration in animal studies. The objective of this study was to examine the analgesic and biochemical effect of LLLT in patients with knee osteoarthritis. Subjects (n = 34) who fulfilled the selection criteria were randomly divided into active group (n = 17) and placebo group. Subjects in active group were irradiated laser with the frequency of 3 days per week for 4 weeks with the specific parameters on 8 different points on the joint at 1.5 J per point for 60 s for 8 points for a total dose of 12 J in a skin contact method. The placebo group was treated with the same probe with minimum emission of energy. Visual analog scale for pain intensity, joint space width, collagen-II telopeptide, and matrix metallo protinease-3, 8, and 13 was measured before treatment and at 4 and 8 weeks following treatment. Data are analyzed with mean values and standard deviation with p 0.05) in both groups which shows homogeneity. After 4- and 8-week treatment, active laser group shows more significant difference (p 0.05). Our results show that low-level laser therapy was more efficient in reducing pain and improving cartilage thickness through biochemical changes.
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