Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies
Aune D, Keum N, Giovannucci E, Fadnes LT, Boffetta P, Greenwood DC, Tonstad S, Vatten LJ, Riboli E, Norat T
BMC medicine · 275 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Norges Teknisk-Naturvitenskapelige Universitet
- Gobierno
- National Institute for Health and Care Research
- Universidad u hospital
- Imperial College London
- Gobierno
- Helse Midt-Norge
- Organización sin fines de lucro
- Olav og Gerd Meidel Raagholt’s Stiftelse for Medisinsk forskning
- Gobierno
- the Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU)
- Universidad u hospital
- Imperial College National Institute of Health Research (NIHR) Biomedical Research Centre (BRC)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-12-01 · BMC Med · vol. 14 · número 1 · pág. 207
- Editorial
- BioMed Central
- Citado
- 411 citas · más que el 100% de estudios similares · 9.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 92 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nuts composition and effects · Peanut Plant Research Studies · Botany, Ecology, and Taxonomy Studies
- Palabras clave
- Medicine, Meta-analysis, Relative risk, Internal medicine, Cause of death, Diabetes mellitus, Confidence interval, Prospective cohort study, Disease, Cancer, Stroke (engine), Endocrinology
- MeSH
- humans, nuts, neoplasms, cardiovascular diseases, diet, mortality, risk, prospective studies, adult
10 autores
- Dagfinn Aune🇳🇴🇬🇧 · autor de correspondenciaNorwegian University of Science and Technology; Imperial College London
- NaNa Keum🇺🇸Harvard University
- Edward L. Giovannucci🇺🇸Brigham and Women's Hospital; Harvard University
- Lars Thore Fadnes🇳🇴University of Bergen
- Paolo Boffetta🇺🇸Tisch Hospital; Icahn School of Medicine at Mount Sinai
- Darren Charles Greenwood🇬🇧University of Leeds
- Serena Tonstad🇳🇴Oslo University Hospital
- LARS JOHAN VATTEN🇳🇴Norwegian University of Science and Technology
- Elio Ríboli🇬🇧Imperial College London
- Teresa Norat🇬🇧Imperial College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Although nut consumption has been associated with a reduced risk of cardiovascular disease and all-cause mortality, data on less common causes of death has not been systematically assessed. Previous reviews missed several studies and additional studies have since been published. We therefore conducted a systematic review and meta-analysis of nut consumption and risk of cardiovascular disease, total cancer, and all-cause and cause-specific mortality.
Methods
PubMed and Embase were searched for prospective studies of nut consumption and risk of cardiovascular disease, total cancer, and all-cause and cause-specific mortality in adult populations published up to July 19, 2016. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated using random-effects models. The burden of mortality attributable to low nut consumption was calculated for selected regions.
Results
Twenty studies (29 publications) were included in the meta-analysis. The summary RRs per 28 grams/day increase in nut intake was for coronary heart disease, 0.71 (95% CI: 0.63-0.80, I2 = 47%, n = 11), stroke, 0.93 (95% CI: 0.83-1.05, I2 = 14%, n = 11), cardiovascular disease, 0.79 (95% CI: 0.70-0.88, I2 = 60%, n = 12), total cancer, 0.85 (95% CI: 0.76-0.94, I2 = 42%, n = 8), all-cause mortality, 0.78 (95% CI: 0.72-0.84, I2 = 66%, n = 15), and for mortality from respiratory disease, 0.48 (95% CI: 0.26-0.89, I2 = 61%, n = 3), diabetes, 0.61 (95% CI: 0.43-0.88, I2 = 0%, n = 4), neurodegenerative disease, 0.65 (95% CI: 0.40-1.08, I2 = 5.9%, n = 3), infectious disease, 0.25 (95% CI: 0.07-0.85, I2 = 54%, n = 2), and kidney disease, 0.27 (95% CI: 0.04-1.91, I2 = 61%, n = 2). The results were similar for tree nuts and peanuts. If the associations are causal, an estimated 4.4 million premature deaths in the America, Europe, Southeast Asia, and Western Pacific would be attributable to a nut intake below 20 grams per day in 2013.
Conclusions
Higher nut intake is associated with reduced risk of cardiovascular disease, total cancer and all-cause mortality, and mortality from respiratory disease, diabetes, and infections.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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