Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies
Fang X, Wang K, Han D, He X, Wei J, Zhao L, Imam MU, Ping Z, Li Y, Xu Y, Min J, Wang F
BMC medicine · 179 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Natural Science Foundation of Zhejiang Province
- Subvenciones
- Natural Science Foundation of Zhejiang Province (LZ15H160002); National Natural Science Foundation of China (31330036); National Natural Science Foundation of China (31401016); National Natural Science Foundation of China (31530034); National Natural Science Foundation of China (31570791); National Natural Science Foundation of China (91542205); National Natural Science Foundation of China (31225013)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-12-01 · BMC Med · vol. 14 · número 1 · pág. 210
- Editorial
- BioMed Central
- Citado
- 266 citas · más que el 96% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 85 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Magnesium Alloys: Properties and Applications
- Palabras clave
- Medicine, Prospective cohort study, Relative risk, Internal medicine, Type 2 diabetes, Cohort study, Meta-analysis, Diabetes mellitus, Stroke (engine), Cohort, Confidence interval, Endocrinology
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, type 2, magnesium, trace elements, survival analysis, prospective studies, dose-response relationship, drug, statistics as topic
12 autores
- Xuexian Fang🇨🇳Beijing Advanced Innovation Center for Food Nutrition and Human Health
- Kai Wang🇨🇳Zhejiang University
- Dan Han🇨🇳Beijing Advanced Innovation Center for Food Nutrition and Human Health
- Xuyan He🇨🇳Beijing Advanced Innovation Center for Food Nutrition and Human Health
- Jiayu Wei🇨🇳Beijing Advanced Innovation Center for Food Nutrition and Human Health
- Lu Zhao🇨🇳Beijing Advanced Innovation Center for Food Nutrition and Human Health
- Mustapha Umar Imam🇨🇳Zhengzhou University
- Zhiguang Ping🇨🇳Zhengzhou University
- Yusheng Li🇨🇳First Affiliated Hospital of Zhengzhou University
- Yuming Xu🇨🇳First Affiliated Hospital of Zhengzhou University
- Junxia Min🇨🇳Zhejiang University
- Fudi Wang🇨🇳 · autor de correspondenciaZhengzhou University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Although studies have examined the association between dietary magnesium intake and health outcome, the results are inconclusive. Here, we conducted a dose-response meta-analysis of prospective cohort studies in order to investigate the correlation between magnesium intake and the risk of cardiovascular disease (CVD), type 2 diabetes (T2D), and all-cause mortality.
Methods
PubMed, EMBASE, and Web of Science were searched for articles that contained risk estimates for the outcomes of interest and were published through May 31, 2016. The pooled results were analyzed using a random-effects model.
Results
Forty prospective cohort studies totaling more than 1 million participants were included in the analysis. During the follow-up periods (ranging from 4 to 30 years), 7678 cases of CVD, 6845 cases of coronary heart disease (CHD), 701 cases of heart failure, 14,755 cases of stroke, 26,299 cases of T2D, and 10,983 deaths were reported. No significant association was observed between increasing dietary magnesium intake (per 100 mg/day increment) and the risk of total CVD (RR: 0.99; 95% CI, 0.88-1.10) or CHD (RR: 0.92; 95% CI, 0.85-1.01). However, the same incremental increase in magnesium intake was associated with a 22% reduction in the risk of heart failure (RR: 0.78; 95% CI, 0.69-0.89) and a 7% reduction in the risk of stroke (RR: 0.93; 95% CI, 0.89-0.97). Moreover, the summary relative risks of T2D and mortality per 100 mg/day increment in magnesium intake were 0.81 (95% CI, 0.77-0.86) and 0.90 (95% CI, 0.81-0.99), respectively.
Conclusions
Increasing dietary magnesium intake is associated with a reduced risk of stroke, heart failure, diabetes, and all-cause mortality, but not CHD or total CVD. These findings support the notion that increasing dietary magnesium might provide health benefits.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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