Vitamin D and type 2 diabetes
Lips P, Eekhoff M, van Schoor N, Oosterwerff M, de Jongh R, Krul-Poel Y, Simsek S
The Journal of steroid biochemistry and molecular biology · 143 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-12-05 · J Steroid Biochem Mol Biol · vol. 173 · págs. 280–285
- Editorial
- Elsevier BV
- Citado
- 224 citas · más que el 98% de estudios similares · 8.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 46 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Diabetes Treatment and Management · Nutrition and Health Studies
- Palabras clave
- vitamin D deficiency, type 2 diabetes, insulin resistance, insulin secretion, pancreatic beta cells, 1,25-dihydroxyvitamin D3, inflammation, genetic polymorphism, 25-hydroxyvitamin D3, metabolic syndrome, fat mass, vitamin D supplementation, impaired glucose tolerance, prediabetes, glycemic control
- MeSH
- animals, humans, diabetes mellitus, type 2, vitamin d deficiency, insulin, blood glucose, vitamins, vitamin d, randomized controlled trials as topic
7 autores
- Paul T.A.M. Lips🇳🇱 · autor de correspondenciaAmsterdam UMC Location Vrije Universiteit Amsterdam
- Elisabeth M. W. Eekhoff🇳🇱Amsterdam UMC Location Vrije Universiteit Amsterdam
- Natasja M. van Schoor🇳🇱Amsterdam UMC Location Vrije Universiteit Amsterdam
- Mirjam M Oosterwerff🇳🇱Catharina Ziekenhuis; Amsterdam UMC Location Vrije Universiteit Amsterdam
- Renate T. de Jongh🇳🇱Amsterdam UMC Location Vrije Universiteit Amsterdam
- Yvonne H M Krul-Poel🇳🇱Medisch Centrum Alkmaar
- Suat Şimşek🇳🇱Medisch Centrum Alkmaar; Amsterdam UMC Location Vrije Universiteit Amsterdam
Resumen
El texto original del estudio, en el idioma en que se publicó.
Vitamin D deficiency is associated with a decreased insulin release, insulin resistance and type 2 diabetes in experimental and epidemiological studies. Animal studies show that 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) stimulates the pancreatic β-cell to secrete insulin. The relationship between vitamin D deficiency and insulin resistance could develop through inflammation, as vitamin D deficiency is associated with increased inflammatory markers. In addition, genetic polymorphisms of vitamin D -related genes may predispose to impaired glycemic control and type 2 diabetes. Epidemiologic studies showed an association between low serum 25-hydroxyvitamin D3 (25(OH)D3) concentration and an increased risk for the metabolic syndrome and type 2 diabetes. This may be partly explained by an increased fat mass. A possible causal relationship between vitamin D deficiency and type 2 diabetes should be proven by randomized clinical trials showing that either type 2 diabetes can be prevented or insulin release and insulin sensitivity can be improved by vitamin D supplements. The results of randomized clinical trials on the effect of vitamin D versus placebo, sometimes combined with calcium, in patients with impaired glucose tolerance ("prediabetes") or type 2 diabetes are inconsistent. Some studies showed a slight decrease of fasting plasma glucose or improvement of insulin resistance, but often only in posthoc analyses. These effects are mainly visible in patients with vitamin D deficiency and impaired glucose tolerance at baseline. Meta-analyses of randomized clinical trials in general did not show significant effects of vitamin D supplementation on glycemic control. Currently, several large scale randomized clinical trials with vitamin D supplementation in doses of 1600-4000IU/d are ongoing with glycemic control or incidence of diabetes mellitus as outcome. Vitamin D deficiency needs to be prevented or cured, but until the results of these trials are published, high-dose vitamin D supplementation cannot be recommended for prevention or amelioration of type 2 diabetes.
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