Acute caffeine ingestion reduces insulin sensitivity in healthy subjects: a systematic review and meta-analysis
Shi X, Xue W, Liang S, Zhao J, Zhang X
Nutrition journal · 54 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Zhengzhou University
- Universidad u hospital
- First Affiliated Hospital of Zhengzhou University
- Subvenciones
- National Natural Science Foundation of China (71673254)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-12-01 · Nutr J · vol. 15 · número 1 · pág. 103
- Editorial
- BioMed Central
- Citado
- 92 citas · más que el 76% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Coffee research and impacts · Circadian rhythm and melatonin · Tea Polyphenols and Effects
- Palabras clave
- Medicine, Caffeine, Meta-analysis, Cochrane Library, Placebo, Glycemic, Ingestion, Diabetes mellitus, Insulin, Randomized controlled trial, Internal medicine, Confidence interval, Glucose homeostasis, Insulin resistance, Endocrinology, Alternative medicine
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, caffeine, insulin, blood glucose, risk factors, coffee, randomized controlled trials as topic
5 autores
- Xiuqin Shi🇨🇳First Affiliated Hospital of Zhengzhou University
- Wenhua Xue🇨🇳First Affiliated Hospital of Zhengzhou University
- Shuhong Liang🇨🇳First Affiliated Hospital of Zhengzhou University
- Jie Zhao🇨🇳 · autor de correspondenciaFirst Affiliated Hospital of Zhengzhou University
- Xiaojian Zhang🇨🇳 · autor de correspondenciaFirst Affiliated Hospital of Zhengzhou University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
According to previous meta-analyses, coffee consumption reduces the risk of type 2 diabetes mellitus. However, the underlying mechanism remains unknown. Whether caffeine, the key ingredient in coffee, has a beneficial effect on the glycemic homeostasis and the anti-diabetic effect is particularly controversial. The aim of this study was to summarize the effect of acute caffeine ingestion on insulin sensitivity in healthy men.
Methods
A comprehensive literature search for papers published before April 2016 was conducted in EMBASE, PubMed, and Cochrane Library databases. Randomized controlled trials (RCTs) that investigated the effect of caffeine on insulin sensitivity in healthy humans without diabetes were included. A random effects meta-analysis was conducted using Review Manager 5.3.
Results
The search yielded 7 RCTs in which caffeine intake was the single variant. Compared with placebo, caffeine intake significantly decreased the insulin sensitivity index, with a standardized mean difference of -2.06 (95% confidence interval -2.67 to -1.44, I2 = 49%, P for heterogeneity = 0.06).
Conclusion
Acute caffeine ingestion reduces insulin sensitivity in healthy subjects. Thus, in the short term, caffeine might shift glycemic homeostasis toward hyperglycemia. Long-term trials investigating the role of caffeine in the anti-diabetic effect of coffee are needed.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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