Low dose of caffeine enhances the efficacy of antidepressants in major depressive disorder and the underlying neural substrates
Liu QS, Deng R, Fan Y, Li K, Meng F, Li X, Liu R
Molecular nutrition & food research · 28 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (81473374); National Natural Science Foundation of China (81473424); National Natural Science Foundation of China (81673411)
Según 1 financiador declarado.
Publicación
- Publicado
- 2017-01-05 · Mol Nutr Food Res · vol. 61 · número 8
- Editorial
- Wiley
- Citado
- 38 citas · más que el 80% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- De pago
- Áreas de investigación
- Treatment of Major Depression · Coffee research and impacts · Tryptophan and brain disorders
- Palabras clave
- caffeine, major depressive disorder, antidepressant efficacy, cognitive performance, sleep, hypothalamic-pituitary-adrenal axis, salivary cortisol, Trier Social Stress Test, combination therapy
- MeSH
- saliva, humans, caffeine, hydrocortisone, antidepressive agents, polysomnography, stress, psychological, cognition, sleep, dietary supplements, adult, middle aged, male, major depressive disorder
7 autores
- Qingshan Liu🇨🇳Minzu University of China
- Ran Deng🇨🇳Minzu University of China
- Yu-Yan Fan🇨🇳Capital Medical University; Beijing Tian Tan Hospital
- Keqin Li🇨🇳Minzu University of China
- Fangang Meng🇨🇳Capital Medical University; Beijing Tian Tan Hospital
- Xueli Li · autor de correspondencia
- Rui Liu🇨🇳 · autor de correspondenciaChinese Academy of Medical Sciences & Peking Union Medical College
Resumen
El texto original del estudio, en el idioma en que se publicó.
Scope
Caffeine is one of the most frequently used psychoactive substances ingested mainly via beverage or food products. Major depressive disorder is a serious and devastating psychiatric disorder. Emerging evidence indicates that caffeine enhances the antidepressant-like activity of common antidepressant drugs in rodents. However, whether joint administration of low dose of caffeine enhances the antidepressant actions in depressed patients remains unclear.
Methods and results
A total of 95 male inpatients were assigned to three groups and were asked to take either caffeine (60, 120 mg) or placebo (soymilk powder) daily for 4 wk on the basis of their current antidepressant medications. Results showed that chronic supplementation with low dose of caffeine (60 mg) produced rapid antidepressant action by reduction of depressive scores. Furthermore, low dose of caffeine improved cognitive performance in depressed patients. However, caffeine did not affect sleep as measured by overnight polysomnography. Moreover, chronic caffeine consumption elicited inhibition of hypothalamic-pituitary-adrenal axis activation by normalization of salivary cortisol induced by Trier social stress test.
Conclusions
These findings indicated the potential benefits of further implications of supplementary administration of caffeine to reverse the development of depression and enhance the outcome of antidepressants treatment in major depressive disorder.
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