Effects of daily blueberry consumption on circulating biomarkers of oxidative stress, inflammation, and antioxidant defense in postmenopausal women with pre- and stage 1-hypertension: a randomized controlled trial
Johnson SA, Feresin RG, Navaei N, Figueroa A, Elam ML, Akhavan NS, Hooshmand S, Pourafshar S, Payton ME, Arjmandi BH
Food & function · 43 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-12-01 · Food Funct · vol. 8 · número 1 · págs. 372–380
- Editorial
- Royal Society of Chemistry
- Citado
- 55 citas · más que el 90% de estudios similares · 2.7× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Antioxidant Activity and Oxidative Stress · Exercise and Physiological Responses
- Palabras clave
- Vaccinium corymbosum, oxidative stress, inflammation, antioxidant defense, 8-hydroxy-2'-deoxyguanosine, oxidative DNA damage, hypertension, prehypertension, stage 1 hypertension, postmenopausal women, dietary intervention, cardiovascular risk
- MeSH
- humans, fruit, hypertension, dna damage, antioxidants, double-blind method, oxidative stress, postmenopause, aged, middle aged, female, biomarkers, blueberry plants
10 autores
- Sarah A. Johnson🇺🇸 · autor de correspondenciaFlorida State University; Colorado State University
- Rafaela G. Feresin🇺🇸Florida State University; University of Arkansas for Medical Sciences
- Negin Navaei🇺🇸Florida State University
- Arturo Figueroa🇺🇸Florida State University
- Marcus L. Elam🇺🇸Florida State University; California State Polytechnic University
- Neda Sara Akhavan🇺🇸Florida State University
- Shirin Hooshmand🇺🇸San Diego State University
- Shirin Pourafshar🇺🇸Florida State University
- Mark E. Payton🇺🇸🇨🇦Oklahoma State University; Stillwater (Canada)
- Bahram Herman Arjmandi🇺🇸Florida State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Oxidative stress and inflammation are central to the development of a number of chronic diseases including cardiovascular disease and previous research suggests that blueberry consumption may attenuate these processes. The present study investigated the effects of blueberries on blood biomarkers of oxidative stress, inflammation, and antioxidant defense in postmenopausal women with pre- and stage 1-hypertension. In a randomized, parallel-arm, double-blind, placebo-controlled clinical trial, 40 pre- and stage 1-hypertensive postmenopausal women aged 45 to 65 years were randomly assigned to receive 22 g freeze-dried highbush blueberry powder per day (Blueberry) or 22 g placebo powder per day (Control) for 8 weeks. A blood biomarker of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine (8-OHdG), as well as blood biomarkers of oxidative stress, inflammation, and antioxidant defense were assessed at baseline, 4 and 8 weeks. 8-OHdG levels were significantly (P = 0.008) lower in Blueberry compared to Control at 4 weeks with a significant time-by-treatment interaction (P = 0.04). Levels were not different between groups at 8 weeks. Other biomarkers measured were not affected by blueberry consumption. Daily consumption of blueberries for 4 weeks, but not 8 weeks, attenuated a biomarker of oxidative DNA damage in pre- and stage 1-hypertensive postmenopausal women. Future clinical studies should directly evaluate the effects of blueberry consumption on oxidative stress, inflammation, and antioxidant defense at the cellular level and in the vasculature in this population.
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