A Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies of Eicosapentaenoic and Docosahexaenoic Long-Chain Omega-3 Fatty Acids and Coronary Heart Disease Risk
Alexander DD, Miller PE, Van Elswyk ME, Kuratko CN, Bylsma LC
Mayo Clinic proceedings · 160 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2017-01-01 · Mayo Clin Proc · vol. 92 · número 1 · págs. 15–29
- Editorial
- Elsevier BV
- Citado
- 251 citas · más que el 99% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 85 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Fatty Acid Research and Health · Natural Products and Biological Research · Eicosanoids and Hypertension Pharmacology
- Palabras clave
- Medicine, Docosahexaenoic acid, Eicosapentaenoic acid, Randomized controlled trial, Coronary heart disease, Meta-analysis, Internal medicine, Cohort study, Prospective cohort study, Disease, Polyunsaturated fatty acid, Fatty acid, Biochemistry
- MeSH
- humans, coronary disease, docosahexaenoic acids, eicosapentaenoic acid, proportional hazards models, risk assessment, prospective studies, randomized controlled trials as topic
5 autores
- Dominik D. Alexander🇺🇸 · autor de correspondenciaMichigan United
- Paige Elizabeth Miller🇺🇸Edward Hines, Jr. VA Hospital
- Mary E. Van Elswyk
- Connye N. Kuratko
- Lauren C. Bylsma🇺🇸Michigan United
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To conduct meta-analyses of randomized controlled trials (RCTs) to estimate the effect of eicosapentaenoic and docosahexaenoic acid (EPA+DHA) on coronary heart disease (CHD), and to conduct meta-analyses of prospective cohort studies to estimate the association between EPA+DHA intake and CHD risk.
Methods
A systematic literature search of Ovid/Medline, PubMed, Embase, and the Cochrane Library from January 1, 1947, to November 2, 2015, was conducted; 18 RCTs and 16 prospective cohort studies examining EPA+DHA from foods or supplements and CHD, including myocardial infarction, sudden cardiac death, coronary death, and angina, were identified. Random-effects meta-analysis models were used to generate summary relative risk estimates (SRREs) and 95% CIs. Heterogeneity was examined in subgroup and sensitivity analyses and by meta-regression. Dose-response was evaluated in stratified dose or intake analyses. Publication bias assessments were performed.
Results
Among RCTs, there was a nonstatistically significant reduction in CHD risk with EPA+DHA provision (SRRE=0.94; 95% CI, 0.85-1.05). Subgroup analyses of data from RCTs indicated a statistically significant CHD risk reduction with EPA+DHA provision among higher-risk populations, including participants with elevated triglyceride levels (SRRE=0.84; 95% CI, 0.72-0.98) and elevated low-density lipoprotein cholesterol (SRRE=0.86; 95% CI, 0.76-0.98). Meta-analysis of data from prospective cohort studies resulted in a statistically significant SRRE of 0.82 (95% CI, 0.74-0.92) for higher intakes of EPA+DHA and risk of any CHD event.
Conclusion
Results indicate that EPA+DHA may be associated with reducing CHD risk, with a greater benefit observed among higher-risk populations in RCTs.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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