Nut Consumption and Lung Cancer Risk: Results from Two Large Observational Studies
Lee JT, Lai GY, Liao LM, Subar AF, Bertazzi PA, Pesatori AC, Freedman ND, Landi MT, Lam TK
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 16 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Association for Cancer Research
- Gobierno
- U.S. Department of Agriculture
- Gobierno
- Regione Lombardia
- Gobierno
- National Institutes of Health
- Gobierno
- Intramural NIH HHS
- Subvenciones
- National Institutes of Health (Z99 CA999999)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2017-01-11 · Cancer Epidemiol Biomarkers Prev · vol. 26 · número 6 · págs. 826–836
- Editorial
- American Association for Cancer Research
- Citado
- 27 citas · más que el 93% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Peanut Plant Research Studies
- Palabras clave
- Observational study, Lung cancer, Medicine, Consumption (sociology), Nut, Internal medicine, Environmental health, Oncology, Engineering
- MeSH
- humans, nuts, lung neoplasms, risk factors, case-control studies, retrospective studies, prospective studies, female, male
9 autores
- Jennifer T. Lee🇺🇸National Institutes of Health
- Gabriel Y. Lai🇺🇸National Institutes of Health
- Linda M. Liao🇺🇸National Institutes of Health
- Amy F. Subar🇺🇸National Institutes of Health
- Pier Alberto Bertazzi🇮🇹University of Milan; Ospedale Maggiore; Istituti di Ricovero e Cura a Carattere Scientifico
- Angela Cecilia Pesatori🇮🇹University of Milan; Ospedale Maggiore; Istituti di Ricovero e Cura a Carattere Scientifico
- Neal D. Freedman🇺🇸National Institutes of Health
- Maria Teresa Landi🇺🇸 · autor de correspondenciaNational Institutes of Health; National Cancer Institute; Cancer Genetics (United States)
- Tram Kim Lam🇺🇸 · autor de correspondenciaNational Institutes of Health
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Epidemiologic evidence on the association between nut consumption and lung cancer risk is limited.Methods: We investigated this relationship in the Environment and Genetics in Lung Cancer Etiology (EAGLE) study, a population-based case-control study, and the National Institutes of Health (NIH) American Association of Retired Persons (AARP) Diet and Health Study, a prospective cohort. We identified 2,098 lung cases for EAGLE and 18,533 incident cases in AARP. Diet was assessed by food frequency questionnaire for both studies. Multivariable ORs and HRs and respective 95% confidence intervals (CI) were calculated using unconditional logistic regression and Cox proportional hazards regression for EAGLE and AARP, respectively.Results: Higher frequency of intake of nut consumption was inversely associated with overall lung cancer risk (highest vs. lowest quintile, OREAGLE = 0.74; 95% CI, 0.57-0.95; HRAARP = 0.86; 95% CI, 0.81-0.91), regardless of smoking status. Results from the prospective cohort showed similar associations across histologic subtypes and a more pronounced benefits from nut consumption for those who smoked 1 to 20 cigarettes/day (OREAGLE = 0.61; 95% CI, 0.39-0.95; HRAARP = 0.83; 95% CI, 0.74-0.94).Conclusions: Nut consumption was inversely associated with lung cancer in two large population-based studies, and associations were independent of cigarette smoking and other known risk factors.Impact: To our knowledge, this is the first study that examined the association between nut consumption and lung cancer risk by histologic subtypes and smoking intensity. Cancer Epidemiol Biomarkers Prev; 26(6); 826-36. ©2017 AACR.
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