Does brain creatine content rely on exogenous creatine in healthy youth? A proof-of-principle study
Merege-Filho CA, Otaduy MC, de Sá-Pinto AL, de Oliveira MO, de Souza Gonçalves L, Hayashi AP, Roschel H, Pereira RM, Silva CA, Brucki SM, da Costa Leite C, Gualano B
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 21 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidad u hospital
- Universidade de São Paulo
Según 3 financiadores declarados.
Publicación
- Publicado
- 2016-10-05 · Appl Physiol Nutr Metab · vol. 42 · número 2 · págs. 128–134
- Editorial
- NRC Research Press
- Citado
- 42 citas · más que el 69% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Cardiovascular and exercise physiology · Sports Performance and Training
- Palabras clave
- Creatine, Hippocampus, Prefrontal cortex, Placebo, Medicine, Psychology, Cognition, Creatine Monohydrate, Internal medicine, Magnetic resonance imaging, Neuropsychology, Endocrinology, Neuroscience, Pathology
- MeSH
- brain, hippocampus, prefrontal cortex, occipital lobe, neurons, humans, creatine, double-blind method, cognition, models, neurological, dietary supplements, child, brazil, female, male, child nutritional physiological phenomena, executive function, performance-enhancing substances, functional neuroimaging, proton magnetic resonance spectroscopy
12 autores
- Carlos Alberto Abujabra Merege-Filho🇧🇷Universidade de São Paulo
- Maria Concepción García Otaduy🇧🇷Universidade de São Paulo
- Ana Lúcia de Sá‐Pinto🇧🇷Universidade de São Paulo
- Maira Okada de Oliveira🇧🇷Universidade de São Paulo
- Lívia de Souza Gonçalves🇧🇷Universidade de São Paulo
- Ana Paula Hayashi🇧🇷Universidade de São Paulo
- Hamilton Roschel🇧🇷Universidade de São Paulo
- Rosa Maria Rodrigues Pereira🇧🇷Universidade de São Paulo
- Clóvis A. Silva🇧🇷Universidade de São Paulo
- Sônia Maria Dozzi Brucki🇧🇷Universidade de São Paulo
- Cláudia da Costa Leite🇧🇷Universidade de São Paulo
- Bruno Gualano🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
It has been hypothesized that dietary creatine could influence cognitive performance by increasing brain creatine in developing individuals. This double-blind, randomized, placebo-controlled, proof-of-principle study aimed to investigate the effects of creatine supplementation on cognitive function and brain creatine content in healthy youth. The sample comprised 67 healthy participants aged 10 to 12 years. The participants were given creatine or placebo supplementation for 7 days. At baseline and after the intervention, participants undertook a battery of cognitive tests. In a random subsample of participants, brain creatine content was also assessed in the regions of left dorsolateral prefrontal cortex, left hippocampus, and occipital lobe by proton magnetic resonance spectroscopy (1H-MRS) technique. The scores obtained from verbal learning and executive functions tests did not significantly differ between groups at baseline or after the intervention (all p > 0.05). Creatine content was not significantly different between groups in left dorsolateral prefrontal cortex, left hippocampus, and occipital lobe (all p > 0.05). In conclusion, a 7-day creatine supplementation protocol did not elicit improvements in brain creatine content or cognitive performance in healthy youth, suggesting that this population mainly relies on brain creatine synthesis rather than exogenous creatine intake to maintain brain creatine homeostasis.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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