Intake of up to 3 Eggs/Day Increases HDL Cholesterol and Plasma Choline While Plasma Trimethylamine-N-oxide is Unchanged in a Healthy Population
DiMarco DM, Missimer A, Murillo AG, Lemos BS, Malysheva OV, Caudill MA, Blesso CN, Fernandez ML
Lipids · 63 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- The Esperance Family Foundation
Según 1 financiador declarado.
Publicación
- Publicado
- 2017-01-13 · Lipids · vol. 52 · número 3 · págs. 255–263
- Editorial
- Wiley
- Citado
- 91 citas · más que el 99% de estudios similares · 10.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 62 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutritional Studies and Diet · Diet and metabolism studies · Gut microbiota and health
- Palabras clave
- Trimethylamine N-oxide, Choline, Lipidology, Clinical chemistry, Cholesterol, Trimethylamine, Chemistry, Population, Plasma, Internal medicine, Endocrinology, Chromatography, Medicine, Biochemistry
- MeSH
- humans, choline, methylamines, anthropometry, blood pressure, eggs, adult, female, male, cholesterol, ldl, cholesterol, hdl, waist circumference, young adult, healthy volunteers
8 autores
- Diana M DiMarco🇺🇸University of Connecticut
- Amanda Missimer🇺🇸University of Connecticut
- Ana Gabriela Murillo🇺🇸University of Connecticut
- Bruno S. Lemos🇺🇸University of Connecticut
- Olga V. Malysheva🇺🇸Cornell University
- Marie A. Caudill🇺🇸Cornell University
- Christopher N. Blesso🇺🇸University of Connecticut
- María Luz Fernández🇺🇸 · autor de correspondenciaUniversity of Connecticut
Resumen
El texto original del estudio, en el idioma en que se publicó.
Eggs are a source of cholesterol and choline and may impact plasma lipids and trimethylamine-N-oxide (TMAO) concentrations, which are biomarkers for cardiovascular disease (CVD) risk. Therefore, the effects of increasing egg intake (0, 1, 2, and 3 eggs/day) on these and other CVD risk biomarkers were evaluated in a young, healthy population. Thirty-eight subjects [19 men/19 women, 24.1 ± 2.2 years, body mass index (BMI) 24.3 ± 2.5 kg/m2] participated in this 14-week crossover intervention. Participants underwent a 2-week washout with no egg consumption, followed by intake of 1, 2, and 3 eggs/day for 4 weeks each. Anthropometric data, blood pressure (BP), dietary records, and plasma biomarkers (lipids, glucose, choline, and TMAO) were measured during each intervention phase. BMI, waist circumference, systolic BP, plasma glucose, and plasma triacylglycerol did not change throughout the intervention. Diastolic BP decreased with egg intake (P < 0.05). Compared to 0 eggs/day, intake of 1 egg/day increased HDL cholesterol (HDL-c) (P < 0.05), and decreased LDL cholesterol (LDL-c) (P < 0.05) and the LDL-c/HDL-c ratio (P < 0.01). With intake of 2-3 eggs/day, these changes were maintained. Plasma choline increased dose-dependently with egg intake (P < 0.0001) while fasting plasma TMAO was unchanged. These results indicate that in a healthy population, consuming up to 3 eggs/day results in an overall beneficial effect on biomarkers associated with CVD risk, as documented by increased HDL-c, a reduced LDL-c/HDL-c ratio, and increased plasma choline in combination with no change in plasma LDL-c or TMAO concentrations.
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