Vitamin D deficiency and the risk of tuberculosis: a meta-analysis
Huang SJ, Wang XH, Liu ZD, Cao WL, Han Y, Ma AG, Xu SF
Drug design, development and therapy · 114 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-12-01 · Drug Des Devel Ther · vol. Volume11 · págs. 91–102
- Editorial
- Dove Medical Press
- Citado
- 171 citas · más que el 95% de estudios similares · 3.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Vitamin D Research Studies · Tuberculosis Research and Epidemiology · Infectious Diseases and Tuberculosis
- Palabras clave
- vitamin D deficiency, tuberculosis, tuberculosis risk factors, latent tuberculosis infection, tuberculosis-associated immune reconstitution inflammatory syndrome, HIV/TB coinfection, antiretroviral therapy, tuberculin skin test conversion, vitamin D supplementation, African populations
- MeSH
- humans, tuberculosis, hiv infections, vitamin d deficiency, antitubercular agents, anti-retroviral agents, risk factors
7 autores
- Shao-Jun Huang🇨🇳Capital Medical University; Beijing Chest Hospital
- Xianhua Wang🇨🇳Qingdao University
- Zhidong Liu🇨🇳Capital Medical University; Beijing Chest Hospital
- Wen-Li Cao🇨🇳Beijing Geriatric Hospital
- Yi Han🇨🇳Capital Medical University; Beijing Chest Hospital
- Aiguo Ma🇨🇳Qingdao University
- Shaofa Xu🇨🇳Capital Medical University; Beijing Chest Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aim
To conduct meta-analyses of all published studies on various aspects of association between vitamin D and tuberculosis (TB).
Methods
PubMed and Web of Knowledge were searched for all properly controlled studies on vitamin D and TB. Pooled odds ratio, mean difference or standardized mean difference, and its corresponding 95% confidence interval were calculated with the Cochrane Review Manager 5.3.
Results
A significantly lower vitamin D level was found in TB patients vs controls; vitamin D deficiency (VDD) was associated with an increased risk of TB, although such an association was lacking in the African population and in the human immunodeficiency virus-infected African population. A significantly lower vitamin D level was found in human immunodeficiency virus-TB-coinfected African patients receiving antiretroviral treatment who developed TB-associated immune reconstitution inflammatory syndrome vs those who did not develop TB-associated immune reconstitution inflammatory syndrome. VDD was associated with an increased risk of developing active TB in those subjects with latent TB infection and with an increased risk of tuberculin skin test conversion/TB infection conversion, and the trend toward a lower vitamin D level in active TB patients vs latent TB infection subjects did not reach statistical significance, indicating that VDD was more likely a risk factor than a consequence of TB. This concept was further strengthened by our result that anti-TB treatment did not affect vitamin D level in TB patients receiving the treatment.
Conclusion
Our analyses revealed an association between vitamin D and TB. VDD is more likely a risk factor for TB than its consequence. More studies are needed to determine whether vitamin D supplementation is beneficial to TB prevention and treatment.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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