Financiado en parte por Danone, Dairy Farmers of Canada
Effect of dietary cholesterol and plant sterol consumption on plasma lipid responsiveness and cholesterol trafficking in healthy individuals
Alphonse PA, Ramprasath V, Jones PJ
The British journal of nutrition · 11 citas
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Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Danone
- Universidad u hospital
- University of Manitoba
- Grupo de la industria
- Dairy Farmers of Canada
- Gobierno
- Agriculture and Agri-Food Canada
Según 4 financiadores declarados.
Publicación
- Publicado
- 2017-01-14 · Br J Nutr · vol. 117 · número 1 · págs. 56–66
- Editorial
- Cambridge University Press
- Citado
- 22 citas · más que el 91% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 74 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Cholesterol and Lipid Metabolism · Fatty Acid Research and Health · Lipoproteins and Cardiovascular Health
- Palabras clave
- Cholesterol, Sterol, Meal, Lathosterol, Crossover study, Chemistry, Internal medicine, Endocrinology, Cholesterol synthesis, Campesterol, Population, Food science, Placebo, Biology, Medicine, Biochemistry, Reductase, Enzyme
- MeSH
- humans, phytosterols, lipids, cholesterol, dietary, diet, cross-over studies, double-blind method, food analysis, biological transport, adolescent, adult, middle aged, lipid metabolism, young adult
3 autores
- Peter A. S. Alphonse🇨🇦University of Manitoba
- Vanu Ramkumar Ramprasath🇨🇦University of Manitoba
- Peter J.H. Jones🇨🇦 · autor de correspondenciaUniversity of Manitoba
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary cholesterol and plant sterols differentially modulate cholesterol kinetics and circulating cholesterol. Understanding how healthy individuals with their inherent variabilities in cholesterol trafficking respond to such dietary sterols will aid in improving strategies for effective cholesterol lowering and alleviation of CVD risk. The objectives of this study were to assess plasma lipid responsiveness to dietary cholesterol v. plant sterol consumption, and to determine the response in rates of cholesterol absorption and synthesis to each sterol using stable isotope approaches in healthy individuals. A randomised, double-blinded, crossover, placebo-controlled clinical trial (n 49) with three treatment phases of 4-week duration were conducted in a Manitoba Hutterite population. During each phase, participants consumed one of the three treatments as a milkshake containing 600 mg/d dietary cholesterol, 2 g/d plant sterols or a control after breakfast meal. Plasma lipid profile was determined and cholesterol absorption and synthesis were measured by oral administration of [3, 4-13C] cholesterol and 2H-labelled water, respectively. Dietary cholesterol consumption increased total (0·16 (sem 0·06) mmol/l, P=0·0179) and HDL-cholesterol (0·08 (sem 0·03) mmol/l, P=0·0216) concentrations with no changes in cholesterol absorption or synthesis. Plant sterol consumption failed to reduce LDL-cholesterol concentrations despite showing a reduction (6 %, P=0·0004) in cholesterol absorption. An over-compensatory reciprocal increase in cholesterol synthesis (36 %, P=0·0026) corresponding to a small reduction in absorption was observed with plant sterol consumption, possibly resulting in reduced LDL-cholesterol lowering efficacy of plant sterols. These data suggest that inter-individual variability in cholesterol trafficking mechanisms may profoundly impact plasma lipid responses to dietary sterols in healthy individuals.
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