Dietary cholesterol promotes repair of demyelinated lesions in the adult brain
Berghoff SA, Gerndt N, Winchenbach J, Stumpf SK, Hosang L, Odoardi F, Ruhwedel T, Böhler C, Barrette B, Stassart R, Liebetanz D, Dibaj P, Möbius W, Edgar JM, Saher G
Nature communications · 115 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Deutsche Forschungsgemeinschaft
- Subvenciones
- Deutsche Forschungsgemeinschaft (SA 2014/2-1)
Según 1 financiador declarado.
Publicación
- Publicado
- 2017-01-24 · Nat Commun · vol. 8 · número 1 · pág. 14241
- Editorial
- Nature Portfolio
- Citado
- 149 citas · más que el 97% de estudios similares · 10.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 70 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- RNA Research and Splicing · Neurogenesis and neuroplasticity mechanisms · MicroRNA in disease regulation
- Palabras clave
- Remyelination, Multiple sclerosis, Cholesterol, Medicine, Myelin, Demyelinating disease, Experimental autoimmune encephalomyelitis, Internal medicine, Endocrinology, Central nervous system, Immunology
- MeSH
- brain, oligodendroglia, axons, cells, cultured, stem cells, animals, mice, inbred c57bl, humans, mice, multiple sclerosis, encephalomyelitis, autoimmune, experimental, disease models, animal, cuprizone, cholesterol, cholesterol, dietary, myelin proteins, cell differentiation, cell proliferation, dietary supplements, male, primary cell culture, biomarkers
15 autores
- Stefan A. Berghoff🇩🇪Max Planck Institute of Experimental Medicine
- Nina Gerndt🇩🇪Max Planck Institute of Experimental Medicine
- Jan Winchenbach🇩🇪Max Planck Institute of Experimental Medicine
- Sina K. Stumpf🇩🇪Max Planck Institute of Experimental Medicine
- Leon Hosang🇩🇪Hertie Foundation
- Francesca Odoardi🇩🇪Hertie Foundation
- Torben Ruhwedel🇩🇪Max Planck Institute of Experimental Medicine
- Carolin Böhler🇩🇪Max Planck Institute of Experimental Medicine
- Benoit Barrette🇩🇪Max Planck Institute of Experimental Medicine
- Ruth Martha Stassart🇩🇪Max Planck Institute of Experimental Medicine; University of Göttingen
- David Liebetanz🇩🇪University of Göttingen
- Payam Dibaj🇩🇪Max Planck Institute of Experimental Medicine
- Wiebke Möbius🇩🇪Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103; Max Planck Institute of Experimental Medicine
- Julia M. Edgar🇩🇪🇨🇦🇬🇧Max Planck Institute of Experimental Medicine; Institute of Infection and Immunity; University of Glasgow
- Gesine Saher🇩🇪 · autor de correspondenciaMax Planck Institute of Experimental Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Multiple Sclerosis (MS) is an inflammatory demyelinating disorder in which remyelination failure contributes to persistent disability. Cholesterol is rate-limiting for myelin biogenesis in the developing CNS; however, whether cholesterol insufficiency contributes to remyelination failure in MS, is unclear. Here, we show the relationship between cholesterol, myelination and neurological parameters in mouse models of demyelination and remyelination. In the cuprizone model, acute disease reduces serum cholesterol levels that can be restored by dietary cholesterol. Concomitant with blood-brain barrier impairment, supplemented cholesterol directly supports oligodendrocyte precursor proliferation and differentiation, and restores the balance of growth factors, creating a permissive environment for repair. This leads to attenuated axon damage, enhanced remyelination and improved motor learning. Remarkably, in experimental autoimmune encephalomyelitis, cholesterol supplementation does not exacerbate disease expression. These findings emphasize the safety of dietary cholesterol in inflammatory diseases and point to a previously unrecognized role of cholesterol in promoting repair after demyelinating episodes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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