Plasma Creatine Kinetics After Ingestion of Microencapsulated Creatine Monohydrate with Enhanced Stability in Aqueous Solutions
Hone M, Kent RM, Scotto di Palumbo A, Bleiel SB, De Vito G, Egan B
Journal of dietary supplements · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Irish Research Council
- Subvenciones
- Irish Research Council (EPSPG201491)
Según 1 financiador declarado.
Publicación
- Publicado
- 2017-01-25 · J Diet Suppl · vol. 14 · número 4 · págs. 433–445
- Editorial
- Taylor & Francis
- Citado
- 1 cita · más que el 1% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 25 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Diet and metabolism studies · Proteins in Food Systems
- Palabras clave
- Creatine, Creatine Monohydrate, Ingestion, Chemistry, Maltodextrin, Bioavailability, Aqueous solution, Placebo, Plasma concentration, Animal science, Endocrinology, Internal medicine, Medicine, Food science, Chromatography, Biochemistry, Pharmacology, Biology, Organic chemistry
- MeSH
- humans, creatine, phytosterols, diosgenin, milk proteins, protein hydrolysates, solutions, double-blind method, random allocation, drug compounding, drug stability, biological availability, eating, adult, male, healthy volunteers
6 autores
- Michelle Hone🇮🇪University College Dublin; Sport Ireland; Dublin City University
- Robert M. Kent🇮🇪AnaBio Technologies (Ireland)
- Alessandro Scotto di Palumbo🇮🇪University College Dublin; Sport Ireland
- Sinéad B. Bleiel🇮🇪AnaBio Technologies (Ireland)
- Giuseppe De Vito🇮🇪University College Dublin; Sport Ireland
- Brendan Egan🇮🇪 · autor de correspondenciaUniversity College Dublin; Sport Ireland; Dublin City University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Creatine monohydrate represents one of the largest sports supplement markets. Enhancing creatine (CRE) stability in aqueous solutions, such as with microencapsulation, represents innovation potential. Ten physically active male volunteers were randomly assigned in a double-blind design to either placebo (PLA) (3-g maltodextrin; n = 5) or microencapsulated CRE (3-g creatine monohydrate; n = 5) conditions. Experimental conditions involved ingestion of the samples in a 70-mL ready-to-drink format. CRE was delivered in a novel microencapsulation matrix material consisting entirely of hydrolyzed milk protein. Three hours after ingestion, plasma creatine concentrations were unchanged during PLA, and averaged ∼45 μM. During CRE, plasma creatine concentration peaked after 30 min at 101.6 ± 14.9 μM (p < 0.05), representing a 2.3-fold increase over PLA. Thereafter, plasma creatine concentration gradually trended downwards but remained significantly elevated (∼50% above resting levels) 3 hr after ingestion. These results demonstrate that the microencapsulated form of creatine monohydrate reported herein remains bioavailable when delivered in aqueous conditions, and has potential utility in ready-to-drink formulations for creatine supplementation.
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