Financiado en parte por Nutricia Research, Nutricia Advanced Medical Nutrition
Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study
Verlaan S, Maier AB, Bauer JM, Bautmans I, Brandt K, Donini LM, Maggio M, McMurdo MET, Mets T, Seal C, Wijers SLJ, Sieber C, Boirie Y, Cederholm T
Clinical nutrition (Edinburgh, Scotland) · 89 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Nutricia Research, Nutricia Advanced Medical Nutrition
Según 1 financiador declarado.
Publicación
- Publicado
- 2017-01-17 · Clin Nutr · vol. 37 · número 2 · págs. 551–557
- Editorial
- Elsevier BV
- Citado
- 158 citas · más que el 98% de estudios similares · 8.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nutrition and Health in Aging · Vitamin D Research Studies · Muscle Physiology and Disorders
- Palabras clave
- Sarcopenia, Medicine, Anabolism, Vitamin D and neurology, Sarcopenic obesity, Internal medicine, Endocrinology, Body mass index, Nutritional Supplementation, Physiology
- MeSH
- muscle, skeletal, humans, vitamins, vitamin d, leucine, dietary proteins, treatment outcome, geriatric assessment, double-blind method, nutritional status, aged, female, male, muscle strength, sarcopenia, whey proteins
14 autores
- Sjors Verlaan🇳🇱 · autor de correspondenciaGGD Amsterdam; Nutricia Research (Netherlands); Vrije Universiteit Amsterdam; Amsterdam UMC Location Vrije Universiteit Amsterdam
- Andrea Britta Maier🇦🇺🇳🇱The Royal Melbourne Hospital; The University of Melbourne; Amsterdam Movement Sciences; Vrije Universiteit Amsterdam
- Jürgen Martin Bauer🇩🇪Carl von Ossietzky Universität Oldenburg
- Ivan Bautmans🇧🇪Vrije Universiteit Brussel
- Kirsten Brandt🇬🇧MRC Elsie Widdowson Laboratory; Newcastle University
- Lorenzo M. Donini🇮🇹Sapienza University of Rome
- Marcello Giuseppe Maggio🇮🇹University of Parma; Stazione Sperimentale per l'Industria delle Pelli e delle Materie Concianti
- Marion E. T. McMurdo🇬🇧University of Dundee; Ninewells Hospital
- Tony F. Mets🇧🇪Vrije Universiteit Brussel
- Chris J. Seal🇬🇧MRC Elsie Widdowson Laboratory; Newcastle University
- Sander L. J. Wijers🇳🇱GGD Amsterdam; Nutricia Research (Netherlands); Vrije Universiteit Amsterdam
- Cornel Christian Sieber🇩🇪Friedrich-Alexander-Universität Erlangen-Nürnberg
- Yves Boirie🇫🇷Unité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; University of Clermont Auvergne; Centre Hospitalier Universitaire de Clermont-Ferrand; Centre de Recherche en Nutrition Humaine d'Auvergne
- Tommy Cederholm🇸🇪Uppsala University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Inadequate nutritional intake and altered response of aging muscles to anabolic stimuli from nutrients contribute to the development of sarcopenia. Nutritional interventions show inconsistent results in sarcopenic older adults, which might be influenced by their basal nutritional status.
Objective
To test if baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations and dietary protein intake influenced changes in muscle mass and function in older adults who received nutritional intervention.
Methods and design
Post-hoc analysis was performed in the PROVIDE study that was a randomized controlled, double blind trial among 380 sarcopenic older adults. This study showed that those who received a vitamin D and leucine-enriched whey protein medical nutrition drink for 13 weeks gained more appendicular muscle mass (aMM), and improved lower-extremity function as assessed by the chair stand test compared with controls. To define low and high groups, a baseline serum concentration of 50 nmol/L 25(OH)D and baseline dietary protein intake of 1.0 g/kg/d were used as cut offs.
Results
At baseline, participants with lower 25(OH)D concentrations showed lower muscle mass, strength and function compared with participants with a high 25(OH)D, while the group with lower protein intake (g/kg/day) had more muscle mass at baseline compared with the participants with higher protein intake. Participants with higher baseline 25(OH)D concentrations and dietary protein intake had, independent of other determinants, greater gain in appendicular muscle mass, skeletal muscle index (aMM/h2), and relative appendicular muscle mass (aMM/body weight × 100%) in response to the nutritional intervention. There was no effect modification of baseline 25(OH)D status or protein intake on change in chair-stand test.
Conclusions
Sufficient baseline levels of 25(OH)D and protein intake may be required to increase muscle mass as a result of intervention with a vitamin D and protein supplement in sarcopenic older adults. This suggests that current cut-offs in the recommendations for vitamin D and protein intake could be considered the "minimum" for adults with sarcopenia to respond adequately to nutrition strategies aimed at attenuating muscle loss.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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