The association of telomere length and serum 25-hydroxyvitamin D levels in US adults: the National Health and Nutrition Examination Survey
Mazidi M, Michos ED, Banach M
Archives of medical science : AMS · 82 citas
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-01-01 · Arch Med Sci · vol. 1 · número 1 · págs. 61–65
- Editorial
- Termedia Publishing House
- Citado
- 98 citas · más que el 99% de estudios similares · 9.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-SA
- Áreas de investigación
- Telomeres, Telomerase, and Senescence · Vitamin D Research Studies · Epigenetics and DNA Methylation
- Palabras clave
- National Health and Nutrition Examination Survey, Medicine, Vitamin D and neurology, Confidence interval, Body mass index, Internal medicine, Demography, Marital status, vitamin D deficiency, Radioimmunoassay, Telomere, Population, Environmental health
3 autores
- Mohsen Mazidi🇨🇳Chinese Academy of Sciences; Institute of Genetics and Developmental Biology
- Erin D. Michos🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Maciej Banach🇵🇱🇺🇸Medical University of Lodz; Hypertension Institute; University of Zielona Góra
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Higher vitamin D levels and longer telomere length (TL) have been associated with lower risk of several chronic diseases and all-cause mortality. However, direct relationships between 25-hydroxyvitamin D (25(OH)D) levels and TL are not well established. Vitamin D could influence TL through its anti-inflammatory properties. This study aimed to assess the relationship between vitamin D levels and TL in US adults.
Material and methods
Participants of the National Health and Nutrition Examination Survey (NHANES) with data available on 25(OH)D and TL measures from 2001 to 2002 were included. 25(OH)D levels were measured by the DiaSorin Radioimmunoassay. We used multivariable-adjusted linear regression models, accounting for the survey design and sample weights.
Results
Of the 4347 eligible participants, 47.0% (n = 2045) were men. The mean age was 42.7 years overall, 49.2 years in men and 42.5 years in women (p = 0.060). After adjustment for age, race, marital status, education, and C-reactive protein, each 1 ng/ml higher 25(OH)D level was associated with a 0.045 (95% confidence interval (CI): 0.032 to 0.059) longer telomere-to-single copy gene (T/S) ratio. This was driven by a significant association in women (0.054 (0.043 to 0.064)) and in men (0.036 (0.020 to 0.052)). However, after we further adjusted for smoking, body mass index, and physical activity, no significant relation was found in the overall sample (β coefficient -0.026, 95% CI: -3.16, 1.67), for men (-0.016 (-3.72, 2.64)), or for women (-0.052 (-6.85, 2.26)).
Conclusions
Our findings support a possible positive association between 25(OH)D levels and telomere length. The implications of this association deserve further investigation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-SA).
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