Financiado en parte por Dairy Management, Almond Board of California
Effects of a very high saturated fat diet on LDL particles in adults with atherogenic dyslipidemia: A randomized controlled trial
Chiu S, Williams PT, Krauss RM
PloS one · 93 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Dairy Management
- Grupo de la industria
- Almond Board of California
- Gobierno
- National Institutes of Health
- Universidad u hospital
- University of California, San Francisco
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Advancing Translational Sciences
- Subvenciones
- National Center for Research Resources (UL1RR024131); National Center for Research Resources (RR 024131); University of California, San Francisco (UL1RR024131); National Institutes of Health (RR024131); National Center for Research Resources (UCSF-CTSI Grant Number UL1 RR024131)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-02-06 · PLoS One · vol. 12 · número 2 · pág. e0170664
- Editorial
- Public Library of Science
- Citado
- 127 citas · más que el 99% de estudios similares · 9.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Cholesterol and Lipid Metabolism · Fatty Acid Research and Health
- Palabras clave
- atherogenic dyslipidemia, small dense LDL, apolipoprotein B, LDL cholesterol, fat replacement, postmenopausal women, men, dietary intervention, LDL subclasses, cardiovascular risk factors, dyslipidemia, hypertriglyceridemia, hypercholesterolemia, hyperglycemia
- MeSH
- humans, lipids, dietary fats, lipoproteins, diet, energy intake, adult, middle aged, female, male, dyslipidemias, atherosclerosis, cholesterol, ldl, biomarkers
3 autores
- Sally Chiu
- Paul T. Williams
- Ronald M. Krauss · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Previous studies have shown that increases in LDL-cholesterol resulting from substitution of dietary saturated fat for carbohydrate or unsaturated fat are due primarily to increases in large cholesterol-enriched LDL, with minimal changes in small, dense LDL particles and apolipoprotein B. However, individuals can differ by their LDL particle distribution, and it is possible that this may influence LDL subclass response.
Objective
The objective of this study was to test whether the reported effects of saturated fat apply to individuals with atherogenic dyslipidemia as characterized by a preponderance of small LDL particles (LDL phenotype B).
Methods
Fifty-three phenotype B men and postmenopausal women consumed a baseline diet (55%E carbohydrate, 15%E protein, 30%E fat, 8%E saturated fat) for 3 weeks, after which they were randomized to either a moderate carbohydrate, very high saturated fat diet (HSF; 39%E carbohydrate, 25%E protein, 36%E fat, 18%E saturated fat) or low saturated fat diet (LSF; 37%E carbohydrate, 25%E protein, 37%E fat, 9%E saturated fat) for 3 weeks.
Results
Compared to the LSF diet, consumption of the HSF diet resulted in significantly greater increases from baseline (% change; 95% CI) in plasma concentrations of apolipoprotein B (HSF vs. LSF: 9.5; 3.6 to 15.7 vs. -6.8; -11.7 to -1.76; p = 0.0003) and medium (8.8; -1.3 to 20.0 vs. -7.3; -15.7 to 2.0; p = 0.03), small (6.1; -10.3 to 25.6 vs. -20.8; -32.8 to -6.7; p = 0.02), and total LDL (3.6; -3.2 to 11.0 vs. -7.9; -13.9 to -1.5; p = 0.03) particles, with no differences in change of large and very small LDL concentrations. As expected, total-cholesterol (11.0; 6.5 to 15.7 vs. -5.7; -9.4 to -1.8; p<0.0001) and LDL-cholesterol (16.7; 7.9 to 26.2 vs. -8.7; -15.4 to -1.4; p = 0.0001) also increased with increased saturated fat intake.
Conclusions
Because medium and small LDL particles are more highly associated with cardiovascular disease than are larger LDL, the present results suggest that very high saturated fat intake may increase cardiovascular disease risk in phenotype B individuals. This trial was registered at clinicaltrials.gov (NCT00895141).
Trial registration
Clinicaltrials.gov NCT00895141.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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