Impact of hot and cold exposure on human skeletal muscle gene expression
Zak RB, Shute RJ, Heesch MW, La Salle DT, Bubak MP, Dinan NE, Laursen TL, Slivka DR
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 25 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of General Medical Sciences
- Gobierno
- NIGMS NIH HHS
- Subvenciones
- National Institute of General Medical Sciences (P20GM109090); National Institute of General Medical Sciences (P20 GM103427)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2016-12-01 · Appl Physiol Nutr Metab · vol. 42 · número 3 · págs. 319–325
- Editorial
- NRC Research Press
- Citado
- 32 citas · más que el 79% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 31 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Adipose Tissue and Metabolism · Muscle metabolism and nutrition · Muscle Physiology and Disorders
- Palabras clave
- Skeletal muscle, Mitochondrial biogenesis, Gene expression, Internal medicine, Endocrinology, Myogenesis, Vastus lateralis muscle, Endurance training, Chemistry, VO2 max, Biogenesis, Biology, Mitochondrion, Gene, Medicine, Biochemistry
- MeSH
- muscle, skeletal, mitochondria, humans, rna, messenger, biopsy, body temperature, exercise, gene expression, gene expression regulation, oxygen consumption, muscle development, adult, male, cold temperature, hot temperature, young adult, proteolysis
8 autores
- Roksana Zak🇺🇸University of Nebraska at Omaha
- Robert J. Shute🇺🇸University of Nebraska at Omaha
- Matthew Heesch🇺🇸University of Nebraska at Omaha
- David Taylor La Salle🇺🇸University of Nebraska at Omaha
- Matthew P. Bubak🇺🇸University of Nebraska at Omaha
- Nicholas E. Dinan🇺🇸University of Nebraska at Omaha
- Terence L. Laursen🇺🇸University of Nebraska at Omaha
- Dustin Russel Slivka🇺🇸University of Nebraska at Omaha
Resumen
El texto original del estudio, en el idioma en que se publicó.
Many human diseases lead to a loss of skeletal muscle metabolic function and mass. Local and environmental temperature can modulate the exercise-stimulated response of several genes involved in mitochondrial biogenesis and skeletal muscle function in a human model. However, the impact of environmental temperature, independent of exercise, has not been addressed in a human model. Thus, the purpose of this study was to compare the effects of exposure to hot, cold, and room temperature conditions on skeletal muscle gene expression related to mitochondrial biogenesis and muscle mass. Recreationally trained male subjects (n = 12) had muscle biopsies taken from the vastus lateralis before and after 3 h of exposure to hot (33 °C), cold (7 °C), or room temperature (20 °C) conditions. Temperature had no effect on most of the genes related to mitochondrial biogenesis, myogenesis, or proteolysis (p > 0.05). Core temperature was significantly higher in hot and cold environments compared with room temperature (37.2 ± 0.1 °C, p = 0.001; 37.1 ± 0.1 °C, p = 0.013; 36.9 ± 0.1 °C, respectively). Whole-body oxygen consumption was also significantly higher in hot and cold compared with room temperature (0.38 ± 0.01 L·min-1, p -1, p -1, respectively). In conclusion, these data show that acute temperature exposure alone does not elicit significant changes in skeletal muscle gene expression. When considered in conjunction with previous research, exercise appears to be a necessary component to observe gene expression alterations between different environmental temperatures in humans.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.