Kodo millet whole grain and bran supplementation prevents high-fat diet induced derangements in a lipid profile, inflammatory status and gut bacteria in mice
Sarma SM, Khare P, Jagtap S, Singh DP, Singh DP, Baboota RK, Podili K, Boparai RK, Kaur J, Bhutani KK, Bishnoi M, Kondepudi KK
Food & function · 26 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Department of Biotechnology, Ministry of Science and Technology, India
- Gobierno
- Department of Science and Technology, Ministry of Science and Technology, India
- Gobierno
- Department of Biotechnology , Ministry of Science and Technology
- Gobierno
- Department of Science and Technology, Ministry of Science and Technology
- Subvenciones
- Department of Biotechnology, Ministry of Science and Technology, India (BT/PR6273/FNS/20/622/2012); Department of Science and Technology, Ministry of Science and Technology, India (SB/FT/LS-224/2012)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2017-01-01 · Food Funct · vol. 8 · número 3 · págs. 1174–1183
- Editorial
- Royal Society of Chemistry
- Citado
- 47 citas · más que el 88% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 37 trabajos
- Acceso
- De pago
- Áreas de investigación
- Diet and metabolism studies · Food composition and properties · Nutritional Studies and Diet
- Palabras clave
- Bran, Whole grains, Food science, Obesity, Lipid profile, Bacteria, Gut flora, Biology, Chemistry, Biochemistry, Endocrinology, Cholesterol, Genetics
- MeSH
- animals, mice, inbred c57bl, humans, mice, bacteria, paspalum, obesity, interleukin-6, dietary fiber, dietary supplements, female, male, adipogenesis, lipid metabolism, diet, high-fat, gastrointestinal microbiome, whole grains
11 autores
- Siddhartha M. Sarma🇷🇺🇮🇳Institute of Engineering Science; BRIC-National Agri-Food and Biomanufacturing Institute; Panjab University
- Pragyanshu Khare🇮🇳BRIC-National Agri-Food and Biomanufacturing Institute
- Sneha Jagtap🇮🇳National Institute of Pharmaceutical Education and Research
- Dhirendra Pratap Singh🇮🇳BRIC-National Agri-Food and Biomanufacturing Institute
- Ritesh Kumar Baboota🇮🇳BRIC-National Agri-Food and Biomanufacturing Institute
- Koteswaraiah Podili🇮🇳Vellore Institute of Technology University
- Ravneet Kaur Boparai🇮🇳Government Medical College
- Jaspreet Kaur🇮🇳 · autor de correspondenciaPanjab University
- Kamlesh K. Bhutani🇮🇳National Institute of Pharmaceutical Education and Research
- Mahendra Bishnoi🇮🇳BRIC-National Agri-Food and Biomanufacturing Institute
- Kanthi Kiran Kondepudi🇮🇳 · autor de correspondenciaBRIC-National Agri-Food and Biomanufacturing Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
The protective role of kodo millet whole grain and bran supplementation in diet induced obesity has not been investigated. Here we have studied the role of kodo millet supplementation in age matched Swiss albino mice that were randomly divided into groups and fed their respective diets for 16 weeks. A high fat diet increased weight gain, reduced glucose tolerance, increased serum lipids, altered hepatic and adipocyte gene expression and caused dysbiosis in the intestinal beneficial bacteria. Kodo millet supplementation did not affect weight gain but it improved glucose tolerance and prevented an increase in the serum cholesterol and lipid parameters (P ≤ 0.05), modulated adipogenesis related gene expression, decreased serum IL-6 and LPS levels (P ≤ 0.05), promoted selected beneficial gut bacterial abundances (Lactobacillus sp., Bifidobacteria, Akkermansia and Roseburia spp.) and improved the total short chain fatty acid production (P ≤ 0.05) and acetate levels (P ≤ 0.05) in cecal contents. This study provides evidence that kodo millet supplementation alleviates high-fat diet induced changes and hence can be incorporated as a functional ingredient for the management of obesity.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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