A Role for Photobiomodulation in the Prevention of Myocardial Ischemic Reperfusion Injury: A Systematic Review and Potential Molecular Mechanisms
Liebert A, Krause A, Goonetilleke N, Bicknell B, Kiat H
Scientific reports · 40 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Animales
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2017-02-09 · Sci Rep · vol. 7 · número 1 · pág. 42386
- Editorial
- Nature Portfolio
- Citado
- 51 citas · más que el 72% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 123 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Cardiac Ischemia and Reperfusion · Photodynamic Therapy Research Studies
- Palabras clave
- low-level laser therapy, myocardial ischemia-reperfusion injury, myocardial infarction, cardioprotection, infarct size, inflammation, tissue repair, inflammatory cytokines, antioxidants, molecular mechanisms, cardiac interventions, coronary revascularization
- MeSH
- cytoskeleton, mitochondria, animals, humans, myocardial reperfusion injury, intercellular signaling peptides and proteins, inflammation mediators, cytokines, antioxidants, risk, dose-response relationship, radiation, signal transduction, oxidation-reduction, time factors, biomarkers, low-level light therapy, bias
5 autores
- Ann D. Liebert🇦🇺The University of Sydney
- Andrew Krause
- Neil Goonetilleke🇦🇺The University of Sydney; Blacktown & Mount Druitt Hospital
- Brian T. Bicknell🇦🇺 · autor de correspondenciaAustralian Catholic University
- Hosen Kiat🇦🇺UNSW Sydney; Macquarie University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Myocardial ischemia reperfusion injury is a negative pathophysiological event that may result in cardiac cell apoptosis and is a result of coronary revascularization and cardiac intervention procedures. The resulting loss of cardiomyocyte cells and the formation of scar tissue, leads to impaired heart function, a major prognostic determinant of long-term cardiac outcomes. Photobiomodulation is a novel cardiac intervention that has displayed therapeutic effects in reducing myocardial ischemia reperfusion related myocardial injury in animal models. A growing body of evidence supporting the use of photobiomodulation in myocardial infarct models has implicated multiple molecular interactions. A systematic review was conducted to identify the strength of the evidence for the therapeutic effect of photobiomodulation and to summarise the current evidence as to its mechanisms. Photobiomodulation in animal models showed consistently positive effects over a range of wavelengths and application parameters, with reductions in total infarct size (up to 76%), decreases in inflammation and scarring, and increases in tissue repair. Multiple molecular pathways were identified, including modulation of inflammatory cytokines, signalling molecules, transcription factors, enzymes and antioxidants. Current evidence regarding the use of photobiomodulation in acute and planned cardiac intervention is at an early stage but is sufficient to inform on clinical trials.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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