Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report
Saltmarche AE, Naeser MA, Ho KF, Hamblin MR, Lim L
Photomedicine and laser surgery · 196 citas
Etiquetas de revisión
Vínculos de autores con la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Reporte de caso (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-02-10 · Photomed Laser Surg · vol. 35 · número 8 · págs. 432–441
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 301 citas · más que el 100% de estudios similares · 16.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Dermatologic Treatments and Research · Photoreceptor and optogenetics research
- Palabras clave
- Medicine, Dementia, Precuneus, Internal medicine, Alzheimer's disease, Cognition, Audiology, Psychiatry, Disease
- MeSH
- humans, alzheimer disease, prognosis, treatment outcome, severity of illness index, risk assessment, sampling studies, neuropsychological tests, aged, aged, 80 and over, female, male, low-level light therapy
5 autores
- Anita E. Saltmarche · autor de correspondencia
- Margaret A. Naeser🇺🇸Boston University; VA Boston Healthcare System
- Kai Fai Ho
- Michael R. Hamblin🇺🇸Harvard University; Massachusetts General Hospital
- Lew Lim
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This study investigated whether patients with mild to moderately severe dementia or possible Alzheimer's disease (AD) with Mini-Mental State Exam (MMSE) Baseline scores of 10-24 would improve when treated with near-infrared photobiomodulation (PBM) therapy.
Background
Animal studies have presented the potential of PBM for AD. Dysregulation of the brain's default mode network (DMN) has been associated with AD, presenting the DMN as an identifiable target for PBM.
Materials and methods
The study used 810 nm, 10 Hz pulsed, light-emitting diode devices combining transcranial plus intranasal PBM to treat the cortical nodes of the DMN (bilateral mesial prefrontal cortex, precuneus/posterior cingulate cortex, angular gyrus, and hippocampus). Five patients with mild to moderately severe cognitive impairment were entered into 12 weeks of active treatment as well as a follow-up no-treatment, 4-week period. Patients were assessed with the MMSE and Alzheimer's Disease Assessment Scale (ADAS-cog) tests. The protocol involved weekly, in-clinic use of a transcranial-intranasal PBM device; and daily at-home use of an intranasal-only device.
Results
There was significant improvement after 12 weeks of PBM (MMSE, p < 0.003; ADAS-cog, p < 0.023). Increased function, better sleep, fewer angry outbursts, less anxiety, and wandering were reported post-PBM. There were no negative side effects. Precipitous declines were observed during the follow-up no-treatment, 4-week period. This is the first completed PBM case series to report significant, cognitive improvement in mild to moderately severe dementia and possible AD cases.
Conclusions
Results suggest that larger, controlled studies are warranted. PBM shows potential for home treatment of patients with dementia and AD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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