Effects of Cholecalciferol vs Calcifediol on Total and Free 25-Hydroxyvitamin D and Parathyroid Hormone
Shieh A, Ma C, Chun RF, Witzel S, Rafison B, Contreras HTM, Wittwer-Schegg J, Swinkels L, Huijs T, Hewison M, Adams JS
The Journal of clinical endocrinology and metabolism · 40 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCATS NIH HHS
- Gobierno
- NIAMS NIH HHS
- Subvenciones
- National Center for Advancing Translational Sciences (UL-1TR000124); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21 AR073018); National Institute of Arthritis and Musculoskeletal and Skin Diseases (P50AR063020); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR063910)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2017-02-10 · J Clin Endocrinol Metab · vol. 102 · número 4 · págs. 1133–1140
- Editorial
- Oxford University Press
- Citado
- 58 citas · más que el 93% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Parathyroid Disorders and Treatments · Thyroid Disorders and Treatments
- Palabras clave
- Cholecalciferol, Calcifediol, Parathyroid hormone, Vitamin D and neurology, Internal medicine, Endocrinology, Medicine, vitamin D deficiency, Calcium
- MeSH
- humans, vitamin d deficiency, calcium, cholecalciferol, calcifediol, parathyroid hormone, vitamin d, adult, middle aged, female, male, young adult
11 autores
- Albert Shieh
- Christina Ma🇺🇸University of California, Los Angeles
- Rene F. Chun
- Sten de Boom Witzel
- Brandon Rafison
- Hannah T. M. Contreras
- Jonas Wittwer-Schegg🇨🇭DSM (Switzerland)
- L M Swinkels🇳🇱Future Diagnostics (Netherlands)
- Tonnie Huijs🇳🇱Future Diagnostics (Netherlands)
- Martin Hewison🇬🇧University of Birmingham
- John S. Adams
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Vitamin D deficiency disproportionately affects nonwhite individuals. Controversy persists over how to best restore low 25D levels, and how to best define vitamin D status [total (protein bound plus free) vs free 25D].
Objective
To assess the effects of vitamin D3 (cholecalciferol, or D3) vs 25-hydroxyvitamin D3 (calcifediol, or 25D3) on total and free 25D in a multiethnic cohort of adults, and whether change in parathyroid hormone (PTH) is more strongly associated with total vs free 25D.
Design
Sixteen-week randomized controlled trial. Biochemistries at 0, 4, 8, and 16 weeks.
Setting
Academic medical center.
Participants
Thirty-five adults ≥18 years of age with 25D levels <20 ng/mL.
Intervention
Sixty micrograms (2400 IU)/d of D3 or 20 μg/d of 25D3.
Main outcome measures
Total and free 25D, and PTH.
Results
Baseline total (16.2 ± 3.7 vs 17.0 ± 2.5 ng/mL; P = 0.4) and free (4.2 ± 0.8 vs 4.7 ± 1.0 pg/mL; P = 0.2) 25D were similar between D3 and 25D3 groups, respectively; 25D3 increased total (+25.5 vs +13.8 ng/mL; P = 0.001) and free (+6.6 vs +3.5 pg/mL; P = 0.03) 25D more than D3. By 4 weeks, 87.5% of 25D3 participants had total 25D levels ≥30 ng/mL, compared with 23.1% of D3 participants (P = 0.001). Change in PTH was associated with both total (P = 0.01) and free 25D (P = 0.04).
Conclusions
25D3 increased total and free 25D levels more rapidly than D3, regardless of race/ethnicity. Free and total 25D were similarly associated with change in PTH.
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