Male caffeine and alcohol intake in relation to semen parameters and in vitro fertilization outcomes among fertility patients
Karmon AE, Toth TL, Chiu YH, Gaskins AJ, Tanrikut C, Wright DL, Hauser R, Chavarro JE, Earth Study Team
Andrology · 41 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Massachusetts General Hospital
- Universidad u hospital
- Harvard T.H. Chan School of Public Health
- Gobierno
- National Institutes of Health
- Universidad u hospital
- School for Public Health Research
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Gobierno
- NICHD NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NIEHS NIH HHS
- Subvenciones
- National Institute of Environmental Health Sciences (R01ES022955); National Institute of Diabetes and Digestive and Kidney Diseases (P30DK046200); National Institute of Diabetes and Digestive and Kidney Diseases (T-32 DK 007703); Eunice Kennedy Shriver National Institute of Child Health and Human Development (L50 HD056672); National Institute of Environmental Health Sciences (P30-ES-000002); National Institute of Environmental Health Sciences (R01 ES009718); National Institutes of Health (ES 000002); National Institutes of Health (P30 DK046200); National Institutes of Health (ES022955); National Institutes of Health (T32 DK007703‐16); National Institutes of Health (ES009718)
Según 10 financiadores declarados.
Publicación
- Publicado
- 2017-02-10 · Andrology · vol. 5 · número 2 · págs. 354–361
- Editorial
- Wiley
- Citado
- 62 citas · más que el 98% de estudios similares · 8.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Reproductive Health and Technologies · Sperm and Testicular Function · Ovarian function and disorders
- Palabras clave
- Semen quality, Quartile, Fertility, Medicine, Semen, Semen analysis, Assisted reproductive technology, Caffeine, Pregnancy, Live birth, Reproductive medicine, Confounding, In vitro fertilisation, Demography, Physiology, Gynecology, Infertility, Biology, Andrology, Population, Internal medicine, Environmental health, Confidence interval
- MeSH
- humans, infertility, caffeine, sperm count, fertilization in vitro, pregnancy rate, prospective studies, alcohol drinking, sperm motility, fertility, pregnancy, adult, female, male, semen analysis
9 autores
- Anatte Emma Karmon🇺🇸 · autor de correspondenciaHarvard University; Massachusetts General Hospital
- Thomas L. Toth🇺🇸Harvard University; Massachusetts General Hospital
- Yu‐Han Chiu🇺🇸Harvard University
- Audrey Jane Gaskins🇺🇸Harvard University
- Cigdem Tanrikut🇺🇸Harvard University; Massachusetts General Hospital
- Diane L. Wright🇺🇸Harvard University; Massachusetts General Hospital
- Russ B. Hauser🇺🇸Harvard University; Massachusetts General Hospital
- Jorge E. Chavarro🇺🇸Brigham and Women's Hospital; Harvard University
- the Earth Study Team
Resumen
El texto original del estudio, en el idioma en que se publicó.
Much of the literature on the impact of male caffeine and alcohol intake on reproductive outcomes has utilized semen quality as a proxy for male fertility, although semen parameters have a limited predictive value for spontaneous pregnancy. The objective of this study was to investigate whether male caffeine and alcohol intakes are associated with semen parameters and assisted reproductive technology outcome. The Environment and Reproductive Health Study, an ongoing prospective cohort study, enrolls subfertile couples presenting for treatment at an academic fertility center (2007-2012). A total of 171 men with 338 semen analyses and 205 assisted reproductive technology cycles were included in this analysis. Diet was assessed using a 131-item food frequency questionnaire. Mixed models adjusting for potential confounders were used to evaluate the relationships of male caffeine and alcohol intakes with semen parameters and assisted reproductive technology outcomes. There was no association between male caffeine and alcohol intake and semen quality. Male caffeine intake was negatively related to live birth after assisted reproductive technologies (p-trend < 0.01), and male alcohol intake was positively related to live birth after assisted reproductive technologies (p-trend = 0.04). Adjusted live birth rate among couples with a male partner in the highest quartile of caffeine intake (≥272 mg/day) compared to couples with a male partner in the lowest quartile of intake (<99 mg/day) was 19% vs. 55%, respectively, p < 0.01. In terms of alcohol intake, adjusted live birth rate among couples with a male partner in the highest quartile of alcohol intake (≥22 g/day) compared to couples with a male partner in the lowest quartile of intake (<3 g/day) was 61% vs. 28%, respectively, p = 0.05. In conclusion, male pre-treatment caffeine and alcohol intakes were associated with live birth after assisted reproductive technologies, but not with semen parameters, among fertility patients.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.