Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, Esposito S, Ganmaa D, Ginde AA, Goodall EC, Grant CC, Griffiths CJ, Janssens W, Laaksi I, Manaseki-Holland S, Mauger D, Murdoch DR, Neale R, Rees JR, Simpson S, Stelmach I, Kumar GT, Urashima M, Camargo CA
BMJ (Clinical research ed.) · 1,282 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- Health Technology Assessment Programme
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- Medical Research Council
- Gobierno
- National Institute for Health Research (NIHR)
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Institute for Health and Care Research (RP-PG-0407-10398); National Heart, Lung, and Blood Institute (U10 HL064313); Health Technology Assessment Programme (13/03/25); National Heart, Lung, and Blood Institute (U10 HL098115); National Institute for Health and Care Research (13/03/25); National Institute for Health and Care Research (HTA/13/03/25)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-02-15 · BMJ · vol. 356 · pág. i6583
- Citado
- 2,088 citas · más que el 100% de estudios similares · 41.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Chronic Obstructive Pulmonary Disease (COPD) Research · Vitamin C and Antioxidants Research
- Palabras clave
- Medicine, Odds ratio, Placebo, Meta-analysis, Internal medicine, Respiratory tract infections, Confidence interval, Randomized controlled trial, Subgroup analysis, Clinical trial, Vitamin, Incidence (geometry), Respiratory system
- MeSH
- humans, respiratory tract infections, vitamin d, dietary supplements, randomized controlled trials as topic
25 autores
- Adrian R. Martineau🇬🇧 · autor de correspondenciaQueen Mary University of London; Asthma UK; Blizard Institute
- David A. Jolliffe🇬🇧Queen Mary University of London; Blizard Institute
- Richard Hooper🇬🇧Queen Mary University of London; Blizard Institute
- Lauren Greenberg🇬🇧Queen Mary University of London; Blizard Institute
- John F. Aloia🇺🇸Winthrop-University Hospital
- Peter Bergman🇸🇪Karolinska Institutet
- Gal Dubnov‐Raz🇮🇱Edmond and Lily Safra Children's Hospital
- Susanna Esposito🇮🇹University of Milan; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Davaasambuu Ganmaa🇺🇸Harvard University
- Adit A. Ginde🇺🇸University of Colorado Denver
- Emma C Goodall🇨🇦McMaster University
- Cameron Charles Grant🇳🇿University of Auckland
- Chris Griffiths🇬🇧Queen Mary University of London; Asthma UK; Blizard Institute
- Wim Janssens🇧🇪Universitair Ziekenhuis Leuven
- Ilkka Laaksi🇫🇮Tampere University; Tampere University
- Semira Manaseki‐Holland🇬🇧University of Birmingham
- David T. Mauger🇺🇸Pennsylvania State University
- David R. Murdoch🇳🇿University of Otago
- Rachel E. Neale🇦🇺QIMR Berghofer Medical Research Institute
- Judy R. Rees🇺🇸Dartmouth College
- Steve Simpson🇦🇺University of Tasmania
- Iwona Stelmach🇵🇱Medical University of Lodz
- Geeta Trilok Kumar🇮🇳University of Delhi
- Mitsuyoshi Urashima🇯🇵Jikei University School of Medicine
- Carlos A. Camargo🇺🇸Harvard University; Massachusetts General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives To assess the overall effect of vitamin D supplementation on risk of acute respiratory tract infection, and to identify factors modifying this effect.Design Systematic review and meta-analysis of individual participant data (IPD) from randomised controlled trials.Data sources Medline, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, ClinicalTrials.gov, and the International Standard Randomised Controlled Trials Number registry from inception to December 2015.Eligibility criteria for study selection Randomised, double blind, placebo controlled trials of supplementation with vitamin D3 or vitamin D2 of any duration were eligible for inclusion if they had been approved by a research ethics committee and if data on incidence of acute respiratory tract infection were collected prospectively and prespecified as an efficacy outcome.Results 25 eligible randomised controlled trials (total 11 321 participants, aged 0 to 95 years) were identified. IPD were obtained for 10 933 (96.6%) participants. Vitamin D supplementation reduced the risk of acute respiratory tract infection among all participants (adjusted odds ratio 0.88, 95% confidence interval 0.81 to 0.96; P for heterogeneity Conclusions Vitamin D supplementation was safe and it protected against acute respiratory tract infection overall. Patients who were very vitamin D deficient and those not receiving bolus doses experienced the most benefit.Systematic review registration PROSPERO CRD42014013953.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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