Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium
Gaksch M, Jorde R, Grimnes G, Joakimsen R, Schirmer H, Wilsgaard T, Mathiesen EB, Njølstad I, Løchen ML, März W, Kleber ME, Tomaschitz A, Grübler M, Eiriksdottir G, Gudmundsson EF, Harris TB, Cotch MF, Aspelund T, Gudnason V, Rutters F, Beulens JW, van 't Riet E, Nijpels G, Dekker JM, Grove-Laugesen D, Rejnmark L, Busch MA, Mensink GB, Scheidt-Nave C, Thamm M, Swart KM, Brouwer IA, Lips P, van Schoor NM, Sempos CT, Durazo-Arvizu RA, Škrabáková Z, Dowling KG, Cashman KD, Kiely M, Pilz S
PloS one · 226 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Karl-Franzens-Universität Graz
- Universidad u hospital
- Medizinische Universität Graz
- Gobierno
- National Institutes of Health
- Gobierno
- Seventh Framework Programme
- Gobierno
- Intramural NIH HHS
- Subvenciones
- National Institutes of Health (Z99 EY999999); Seventh Framework Programme (613977); National Institutes of Health (Z01 EY000401); National Institutes of Health (ZIA EY000401)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-02-16 · PLoS One · vol. 12 · número 2 · pág. e0170791
- Editorial
- Public Library of Science
- Citado
- 355 citas · más que el 100% de estudios similares · 9.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 46 trabajos
- Acceso
- Acceso abierto (revista) · PUBLIC-DOMAIN
- Áreas de investigación
- Vitamin D Research Studies · Vitamin C and Antioxidants Research · Digestive system and related health
- Palabras clave
- Vitamin D and neurology, Meta-analysis, Medicine, MEDLINE, vitamin D deficiency, Gerontology, Internal medicine, Biology, Biochemistry
- MeSH
- humans, vitamin d deficiency, vitamin d, survival rate, prospective studies, reference standards, aged, middle aged, europe, female, male
41 autores
- Martin Gaksch🇦🇹Medical University of Graz
- Rolf Jorde🇳🇴UiT The Arctic University of Norway
- Guri Grimnes🇳🇴UiT The Arctic University of Norway
- Ragnar Martin Joakimsen🇳🇴UiT The Arctic University of Norway
- Henrik Schirmer🇳🇴UiT The Arctic University of Norway
- Tom Wilsgaard🇳🇴UiT The Arctic University of Norway
- Ellisiv B. Mathiesen🇳🇴UiT The Arctic University of Norway
- Inger Njølstad🇳🇴UiT The Arctic University of Norway
- Maja‐Lisa Løchen🇳🇴UiT The Arctic University of Norway
- Winfried März🇩🇪🇦🇹University of Mannheim; Medical University of Graz; Heidelberg University; University Hospital Heidelberg; Synlab (Germany)
- Marcus Edi Kleber🇩🇪University of Mannheim; Universität Ulm; Heidelberg University; University Hospital Heidelberg
- Andreas Tomaschitz🇦🇹🇩🇪Medical University of Graz; Charité - Universitätsmedizin Berlin
- Martin Robert Grübler🇦🇹🇨🇭Medical University of Graz; University Hospital of Bern
- Guðný Eiríksdóttir🇮🇸Icelandic Heart Association
- Elias Freyr Gudmundsson🇮🇸Icelandic Heart Association
- Tamara B. Harris🇺🇸National Institute on Aging
- Mary Frances Cotch🇺🇸National Eye Institute
- Thor Aspelund🇮🇸University of Iceland; Icelandic Heart Association
- Vilmundur G. Gudnason🇮🇸University of Iceland; Icelandic Heart Association
- Femke Rutters🇳🇱Amsterdam Public Health
- Joline W. J. Beulens🇳🇱University Medical Center Utrecht; Amsterdam Public Health
- Esther van ‘t Riet🇳🇱Amsterdam Public Health
- Giel Nijpels🇳🇱Amsterdam Public Health
- Joost Dekker🇳🇱Amsterdam Public Health
- Diana Grove‐Laugesen🇩🇰Aarhus University Hospital
- Lars Rejnmark🇩🇰Aarhus University Hospital
- Markus Alexander Busch🇩🇪Robert Koch Institute
- Gert Mensink🇩🇪Robert Koch Institute
- Christa Scheidt‐Nave🇩🇪Robert Koch Institute
- Michael Thamm🇩🇪Robert Koch Institute
- Karin M. A. Swart🇳🇱Amsterdam Public Health
- Ingeborg A. Brouwer🇳🇱Amsterdam Public Health
- Paul T.A.M. Lips🇳🇱Amsterdam UMC Location Vrije Universiteit Amsterdam
- Natasja M. van Schoor🇳🇱Amsterdam Public Health
- Christopher T. Sempos🇺🇸Office of Dietary Supplements
- Ramón Durazo-Arvizú🇺🇸Loyola University Medical Center
- Zuzana Škrabáková🇮🇪University College Cork
- Kirsten G. Dowling🇮🇪University College Cork
- Kevin D. Cashman🇮🇪University College Cork
- Mairead E Kiely🇮🇪University College Cork
- Stefan Pilz🇦🇹🇳🇱 · autor de correspondenciaMedical University of Graz; Amsterdam Public Health
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D deficiency may be a risk factor for mortality but previous meta-analyses lacked standardization of laboratory methods for 25-hydroxyvitamin D (25[OH]D) concentrations and used aggregate data instead of individual participant data (IPD). We therefore performed an IPD meta-analysis on the association between standardized serum 25(OH)D and mortality.
Methods
In a European consortium of eight prospective studies, including seven general population cohorts, we used the Vitamin D Standardization Program (VDSP) protocols to standardize 25(OH)D data. Meta-analyses using a one step procedure on IPD were performed to study associations of 25(OH)D with all-cause mortality as the primary outcome, and with cardiovascular and cancer mortality as secondary outcomes. This meta-analysis is registered at ClinicalTrials.gov, number NCT02438488.
Findings
We analysed 26916 study participants (median age 61.6 years, 58% females) with a median 25(OH)D concentration of 53.8 nmol/L. During a median follow-up time of 10.5 years, 6802 persons died. Compared to participants with 25(OH)D concentrations of 75 to 99.99 nmol/L, the adjusted hazard ratios (with 95% confidence interval) for mortality in the 25(OH)D groups with 40 to 49.99, 30 to 39.99, and <30 nmol/L were 1.15 (1.00-1.29), 1.33 (1.16-1.51), and 1.67 (1.44-1.89), respectively. We observed similar results for cardiovascular mortality, but there was no significant linear association between 25(OH)D and cancer mortality. There was also no significantly increased mortality risk at high 25(OH)D levels up to 125 nmol/L.
Interpretation
In the first IPD meta-analysis using standardized measurements of 25(OH)D we observed an association between low 25(OH)D and increased risk of all-cause mortality. It is of public health interest to evaluate whether treatment of vitamin D deficiency prevents premature deaths.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC0).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.