Enhanced neural activation with blueberry supplementation in mild cognitive impairment
Boespflug EL, Eliassen JC, Dudley JA, Shidler MD, Kalt W, Summer SS, Stein AL, Stover AN, Krikorian R
Nutritional neuroscience · 125 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (R01 AG034617); National Institute on Aging (AG034617-01S2)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2017-02-21 · Nutr Neurosci · vol. 21 · número 4 · págs. 297–305
- Editorial
- Taylor & Francis
- Citado
- 170 citas · más que el 96% de estudios similares · 4.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Plant Gene Expression Analysis · Ginkgo biloba and Cashew Applications
- Palabras clave
- Neurocognitive, Dementia, Functional magnetic resonance imaging, Cognition, Effects of sleep deprivation on cognitive performance, Medicine, Cognitive decline, Episodic memory, Randomized controlled trial, Population, Audiology, Placebo, Neuropsychology, Psychology, Internal medicine, Neuroscience, Psychiatry
- MeSH
- brain, frontal lobe, prefrontal cortex, parietal lobe, humans, fruit, dementia, anthocyanins, magnetic resonance imaging, double-blind method, memory, short-term, dietary supplements, aged, aged, 80 and over, female, male, blueberry plants, cognitive dysfunction
9 autores
- Erin L. Boespflug🇺🇸University of Cincinnati Medical Center
- James C. Eliassen🇺🇸University of Cincinnati Medical Center
- Jonathan A. Dudley🇺🇸University of Cincinnati Medical Center
- Marcelle D. Shidler🇺🇸University of Cincinnati Medical Center
- Wilhelmina Kalt🇨🇦Agriculture and Agri-Food Canada
- Suzanne S. Summer🇺🇸Cincinnati Children's Hospital Medical Center
- Amanda L. Stein🇺🇸University of Cincinnati Medical Center
- Amanda Nicole Stover🇺🇸University of Cincinnati Medical Center
- Robert Krikorian🇺🇸 · autor de correspondenciaUniversity of Cincinnati Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Preclinical studies have shown that blueberry supplementation can improve cognitive performance and neural function in aged animals and have identified associations between anthocyanins and such benefits. Preliminary human trials also suggest cognitive improvement in older adults, although direct evidence of enhancement of brain function has not been demonstrated. In this study, we investigated the effect of blueberry supplementation on regional brain activation in older adults at risk for dementia.
Methods
In a randomized, double-blind, placebo-controlled trial we performed pre- and post-intervention functional magnetic resonance imaging during a working memory (WM) task to assess the effect of blueberry supplementation on blood oxygen level-dependent (BOLD) signal in older adults with mild cognitive impairment, a risk condition for dementia.
Results
Following daily supplementation for 16 weeks, blueberry-treated participants exhibited increased BOLD activation in the left pre-central gyrus, left middle frontal gyrus, and left inferior parietal lobe during WM load conditions (corrected P < 0.01). There was no clear indication of WM enhancement associated with blueberry supplementation. Diet records indicated no between-group difference in anthocyanin consumption external to the intervention.
Discussion
These data demonstrate, for the first time, enhanced neural response during WM challenge in blueberry-treated older adults with cognitive decline and are consistent with prior trials showing neurocognitive benefit with blueberry supplementation in this at-risk population.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.