High Dietary Magnesium Intake is Significantly and Independently Associated with Higher Insulin Sensitivity in a Mexican-Mestizo Population: A Brief Cross-Sectional Report
Moctezuma-Velázquez C, Gómez-Sámano MÁ, Cajas-Sánchez MB, Reyes-Molina DL, Galindo-Guzmán M, Meza-Arana CE, Cuevas-Ramos D, Gómez-Pérez FJ, Gulias-Herrero A
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion · 6 citas
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Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2017-01-01 · Rev Invest Clin · vol. 69 · número 1 · págs. 40–46
- Editorial
- Permanyer
- Citado
- 9 citas · más que el 69% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- Insulin resistance, Homeostatic model assessment, Medicine, Internal medicine, Endocrinology, Homeostasis, Insulin, Type 2 diabetes, Diabetes mellitus, Magnesium, Magnesium deficiency (plants), Glucose tolerance test, Population, Chemistry, Environmental health
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, magnesium, insulin, glucose tolerance test, diet, linear models, cross-sectional studies, adult, mexico, female, male, ethnicity
9 autores
- Carlos Moctezuma‐Velázquez🇲🇽Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
- Miguel Ángel Gómez-Sámano🇲🇽Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
- María Belén Cajas-Sánchez🇪🇨Universidad Católica de Santiago de Guayaquil
- Diana Lorena Reyes-Molina🇪🇨Universidad Católica de Santiago de Guayaquil
- Mariana Galindo-Guzmán🇲🇽Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
- Clara-Elena Meza-Arana🇲🇽Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
- Daniel Cuevas Ramos🇲🇽Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
- Francisco Javier Gomez-Perez🇲🇽Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
- Alfonso Gulı́as-Herrero🇲🇽Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Magnesium acts as a cofactor in many intracellular reactions including phosphorylation of the insulin receptor; therefore, its imbalance can potentially cause insulin resistance. Low serum magnesium concentration has been associated with the development of metabolic syndrome and type 2 diabetes mellitus.
Objective
To study the association between the daily dietary magnesium intake and insulin resistance estimated by the homeostatic model assessment of insulin resistance and homeostatic model assessment 2, as well as insulin sensitivity estimated by the Matsuda index.
Methods
In a university affiliated medical center, 32 participants (22 women, 10 men) that had an indication for testing for type 2 diabetes mellitus with an oral glucose tolerance test were enrolled in this cross-sectional, comparative study. Clinical and biochemical evaluations were carried out including an oral glucose tolerance test. Hepatic insulin resistance index, homeostatic model assessment 2, homeostatic model assessment of insulin resistance, and Matsuda insulin sensitivity were calculated for each participant. They were asked to recall their food ingestion (24 hours) of three days of the past week, including a weekend day; magnesium intake was calculated according to the food nutritional information.
Results
The low dietary magnesium intake group (< 4.5 mg/kg/day) had a higher two-hour insulin concentration after an oral glucose tolerance test compared to those with high dietary magnesium (119.5 [73.0-190.6] vs. 63.5 [25.4-114.2]; p = 0.008), and insulin sensitivity assessed by the Matsuda index was higher in the high dietary magnesium intake group (4.3 ± 3.1 vs. 2.4 ± 1.5; p = 0.042). In multiple linear regression analysis a higher dietary magnesium intake was independently associated (β = 4.93; p = 0.05) with a better insulin sensitivity estimated by the Matsuda index.
Conclusions
Our results suggest that higher magnesium intake is independently associated with better insulin sensitivity in patients at risk for type 2 diabetes mellitus.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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