Effect of magnesium supplementation on depression status in depressed patients with magnesium deficiency: A randomized, double-blind, placebo-controlled trial
Rajizadeh A, Mozaffari-Khosravi H, Yassini-Ardakani M, Dehghani A
Nutrition (Burbank, Los Angeles County, Calif.) · 55 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-11-09 · Nutrition · vol. 35 · págs. 56–60
- Editorial
- Elsevier BV
- Citado
- 79 citas · más que el 96% de estudios similares · 5.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Treatment of Major Depression · Magnesium Alloys: Properties and Applications
- Palabras clave
- magnesium supplementation, hypomagnesemia, depression, magnesium oxide, serum magnesium, Beck Depression Inventory-II, antidepressant effects
- MeSH
- humans, magnesium deficiency, magnesium, treatment outcome, follow-up studies, double-blind method, depression, psychiatric status rating scales, dietary supplements, adult, female, male, young adult
4 autores
- Afsaneh Rajizadeh🇮🇷Shahid Sadoughi University of Medical Sciences and Health Services
- Hassan Mozaffari–Khosravi🇮🇷 · autor de correspondenciaShahid Sadoughi University of Medical Sciences and Health Services
- Mojtaba Yassini-Ardakani🇮🇷Shahid Sadoughi University of Medical Sciences and Health Services
- Ali Dehghani🇮🇷Shahid Sadoughi University of Medical Sciences and Health Services
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
The aim of this study was to determine the effect of magnesium supplementation on the depression status of depressed patients suffering from magnesium deficiency.
Methods
Sixty depressed people suffering from hypomagnesemia participated in this trial. The individuals were randomly categorized into two groups of 30 members; one receiving two 250-mg tablets of magnesium oxide (MG) daily and the other receiving placebo (PG) for 8 wk. The Beck Depression Inventory-II was conducted and the concentration of serum magnesium was measured.
Results
At the end of intervention, 88.5% of the MG and 48.1% of the PG (P = 0.002) had a normal level of magnesium. The mean changes of serum magnesium were significantly different across the two groups. After the intervention, the mean Beck score significantly declined. However, in the MG, this reduction was more significant than in the PG (P = 0.02), so that the mean changes in this group experienced 15.65 ± 8.9 reduction, but in the PG, it declined by 10.40 ± 7.9.
Conclusions
Daily consumption of 500 mg magnesium oxide tablets for ≥8 wk by depressed patients suffering from magnesium deficiency leads to improvements in depression status and magnesium levels. Therefore, assessment of the magnesium serum and resolving this deficiency positively influence the treatment of depressed patients.
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