Serum 25-hydroxyvitamin D and the risk of cardiovascular disease: dose-response meta-analysis of prospective studies
Zhang R, Li B, Gao X, Tian R, Pan Y, Jiang Y, Gu H, Wang Y, Wang Y, Liu G
The American journal of clinical nutrition · 158 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Beijing Municipal Science and Technology Commission
- Subvenciones
- National Natural Science Foundation of China (2016-1); Beijing Municipal Science and Technology Commission (D131100002313002); National Natural Science Foundation of China (81471208); Beijing Municipal Science and Technology Commission (2016-1-2041)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2017-03-02 · Am J Clin Nutr · vol. 105 · número 4 · págs. 810–819
- Editorial
- Elsevier BV
- Citado
- 202 citas · más que el 97% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 82 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Cardiovascular Health and Risk Factors
- Palabras clave
- 25-hydroxyvitamin D, vitamin D, cardiovascular disease, cardiovascular mortality, dose-response relationship, nonlinear relationship, serum vitamin D levels, cardiovascular risk
- MeSH
- humans, cardiovascular diseases, vitamin d deficiency, vitamin d, risk factors, prospective studies, adult, aged, aged, 80 and over, middle aged
10 autores
- Runhua Zhang🇨🇳Capital Medical University; Beijing Tian Tan Hospital; Beijing Institute for Brain Disorders
- Bohong Li🇨🇳Capital Medical University; Beijing Tian Tan Hospital
- Xiang Gao🇺🇸Pennsylvania State University
- Rui Tian🇨🇳Capital Medical University; Beijing Tian Tan Hospital
- Yuesong Pan🇨🇳Capital Medical University; Beijing Tian Tan Hospital; Beijing Institute for Brain Disorders
- Yong Jiang🇨🇳Capital Medical University; Beijing Tian Tan Hospital; Beijing Institute for Brain Disorders
- Hongqiu Gu🇨🇳Capital Medical University; Beijing Tian Tan Hospital; Beijing Institute for Brain Disorders
- Yilong Wang🇨🇳Capital Medical University; Beijing Tian Tan Hospital; Beijing Institute for Brain Disorders
- Yongjun Wang🇨🇳Capital Medical University; Beijing Tian Tan Hospital; Beijing Institute for Brain Disorders
- Gaifen Liu🇨🇳 · autor de correspondenciaCapital Medical University; Beijing Tian Tan Hospital; Beijing Institute for Brain Disorders
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: During the past decade, an increasing number of prospective studies have focused on the association between vitamin D and cardiovascular disease (CVD). However, the evidence on the relation between serum 25-hydroxyvitamin D [25(OH)D] and the risk of overt CVD is inconclusive.Objective: We performed a dose-response meta-analysis to summarize and prospectively quantify the RR of low serum 25(OH)D concentration and total CVD (events and mortality).Design: We identified relevant studies by searching PubMed and EMBASE up to December 2015 and by hand-searching reference lists. Prospective studies based on the general population and reported RRs and 95% CIs were included. A random-effects model was used to calculate the pooled RRs. Nonlinear association was assessed by using restricted cubic spline analyses.Results: A total of 34 publications with 180,667 participants were eligible for the meta-analysis. We included 32 publications (27 independent studies) for total CVD events and 17 publications (17 independent studies) for CVD mortality. We observed an inverse association between serum 25(OH)D and total CVD events and CVD mortality, and the pooled RRs per 10-ng/mL increment were 0.90 (95% CI: 0.86, 0.94) for total CVD events and 0.88 (95% CI: 0.80, 0.96) for CVD mortality. A nonlinear association was detected for total CVD events (P-nonlinear P-nonlinear = 0.022).Conclusion: Serum 25(OH)D concentration was inversely associated with total CVD events and CVD mortality from the observed studies.
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