Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults
Joris PJ, Plat J, Bakker SJ, Mensink RP
Scientific reports · 32 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-03-01 · Sci Rep · vol. 7 · número 1 · pág. 106
- Editorial
- Nature Portfolio
- Citado
- 48 citas · más que el 90% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Magnesium in Health and Disease · Parathyroid Disorders and Treatments
- Palabras clave
- Medicine, Arterial stiffness, Overweight, Brachial artery, Internal medicine, Reactive hyperemia, Endothelial dysfunction, Placebo, Randomized controlled trial, Body mass index, Endocrinology, Endothelium, Type 2 diabetes, Diabetes mellitus, Vasodilation, Cardiology, Blood pressure, Pathology
- MeSH
- brachial artery, humans, obesity, magnesium, double-blind method, postmenopause, vasodilation, dietary supplements, aged, middle aged, female, male, overweight, vascular stiffness, biomarkers
4 autores
- Peter J. Joris🇳🇱🇺🇸 · autor de correspondenciaMaastricht University Medical Centre; University Medical Center; Maastricht University; TiFN
- Jogchum Plat🇺🇸🇳🇱University Medical Center; Maastricht University
- Stephan J. L. Bakker🇳🇱University Medical Center Groningen; University of Groningen
- Ronald P. Mensink🇺🇸🇳🇱University Medical Center; Maastricht University; TiFN
Resumen
El texto original del estudio, en el idioma en que se publicó.
Long-term magnesium supplementation improves arterial stiffness, a cardiovascular disease risk marker. Effects on endothelial function may be another mechanism whereby increased magnesium intakes affect cardiovascular risk. Therefore, a 24-week, randomized, double-blind, placebo-controlled trial was performed to examine effects of magnesium supplementation on endothelial function and cardiometabolic risk markers. Fifty-two overweight and obese subjects (30 men and 22 women, age 62 ± 6 years) were randomized to receive either three times daily magnesium (total dose: 350 mg) or placebo capsules. Endothelial function was assessed at the start and at the end of the study. Cardiometabolic risk markers were measured at baseline, after 12 weeks, and at week 24. Brachial artery flow-mediated vasodilation did not change following long-term magnesium supplementation (0.49 pp; 95% CI: -0.38 to 1.36 pp; P = 0.26). Changes in reactive hyperemia index, retinal microvascular caliber and plasma markers for microvascular endothelial function (sVCAM-1, sICAM-1 and sE-selectin) were also not different. In addition, no effects on serum lipids, plasma glucose, insulin sensitivity, and low-grade systemic inflammation were observed. In conclusion, a daily magnesium supplement of 350 mg for 24 weeks does not improve endothelial function and cardiometabolic risk markers in overweight and obese middle-aged and elderly adults.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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