Tea catechin and caffeine activate brown adipose tissue and increase cold-induced thermogenic capacity in humans
Yoneshiro T, Matsushita M, Hibi M, Tone H, Takeshita M, Yasunaga K, Katsuragi Y, Kameya T, Sugie H, Saito M
The American journal of clinical nutrition · 84 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministry of Education, Culture, Sports, Science and Technology
- Gobierno
- Japan Society for the Promotion of Science
- Subvenciones
- Japan Society for the Promotion of Science (16K15485); Ministry of Education, Culture, Sports, Science and Technology (26860703); Japan Society for the Promotion of Science (16H01877); Ministry of Education, Culture, Sports, Science and Technology (24240092); Japan Society for the Promotion of Science (14J10103); Japan Society for the Promotion of Science (17K00872)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2017-03-08 · Am J Clin Nutr · vol. 105 · número 4 · págs. 873–881
- Editorial
- Elsevier BV
- Citado
- 105 citas · más que el 98% de estudios similares · 7.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Adipose Tissue and Metabolism · Tea Polyphenols and Effects · Coffee research and impacts
- Palabras clave
- caffeine, brown adipose tissue, cold-induced thermogenesis, non-shivering thermogenesis, total energy expenditure, thermogenic effect, green tea
- MeSH
- humans, camellia sinensis, catechin, caffeine, plant extracts, cross-over studies, single-blind method, adaptation, physiological, energy metabolism, thermogenesis, tea, adult, male, adipose tissue, brown, cold temperature, young adult
10 autores
- Takeshi Yoneshiro · autor de correspondencia
- Mami Matsushita🇯🇵Tenshi College
- Masanobu Hibi🇯🇵Kao Corporation (Japan)
- Hiroshi Tone🇯🇵Kao Corporation (Japan)
- Masao Takeshita🇯🇵Kao Corporation (Japan)
- Koichi Yasunaga🇯🇵Kao Corporation (Japan)
- Yoshihisa Katsuragi🇯🇵Kao Corporation (Japan)
- Toshimitsu Kameya
- Hiroki Sugie
- Masayuki Saito🇯🇵Hokkaido University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: The thermogenic effects of green tea catechin have been repeatedly reported, but their mechanisms are poorly understood.Objective: The aim of this study was to investigate the acute and chronic effects of catechin on brown adipose tissue (BAT), a site specialized for nonshivering thermogenesis, in humans.Design: Fifteen healthy male volunteers underwent fluorodeoxyglucose-positron emission tomography to assess BAT activity. To examine the acute catechin effect, whole-body energy expenditure (EE) after a single oral ingestion of a beverage containing 615 mg catechin and 77 mg caffeine (catechin beverage) was measured. Next, to investigate the chronic catechin effects, 10 men with low BAT activity were enrolled. Before and after ingestion of the catechin beverage 2 times/d for 5 wk, cold-induced thermogenesis (CIT) after 2 h of cold exposure at 19°C, which is proportional to BAT activity, was examined. Both the acute and chronic trials were single-blinded, randomized, placebo-controlled, season-matched crossover studies.Results: A single ingestion of the catechin beverage increased EE in 9 subjects who had metabolically active BAT (mean ± SEM: +15.24 ± 1.48 kcal, P P = 0.003). Daily ingestion of the catechin beverage elevated mean ± SEM CIT (from 92.0 ± 26.5 to 197.9 ± 27.7 kcal/d; P = 0.009), whereas the placebo beverage did not change it.Conclusion: Orally ingested tea catechin with caffeine acutely increases EE associated with increased BAT activity and chronically elevates nonshivering CIT, probably because of the recruitment of BAT, in humans. These trials were registered at www.umin.ac.jp/ctr/ as UMIN000016361.
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