The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis
Vaughan-Shaw PG, O'Sullivan F, Farrington SM, Theodoratou E, Campbell H, Dunlop MG, Zgaga L
British journal of cancer · 124 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Cancer Research UK
- Gobierno
- Medical Research Council
- Subvenciones
- Medical Research Council (MR/M004007/1); Cancer Research UK (18927); Cancer Research UK (12076); Medical Research Council (MR/K018647/1)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2017-03-16 · Br J Cancer · vol. 116 · número 8 · págs. 1092–1110
- Editorial
- Springer Nature
- Citado
- 165 citas · más que el 96% de estudios similares · 4.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 140 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Vitamin C and Antioxidants Research · Biotin and Related Studies
- Palabras clave
- FokI, Calcitriol receptor, Vitamin D and neurology, Meta-analysis, Internal medicine, Medicine, Hazard ratio, Context (archaeology), Oncology, Cancer, vitamin D deficiency, Bioinformatics, Genotype, Gastroenterology, Biology, Genetics, Confidence interval, Polymorphism (computer science), Gene
- MeSH
- humans, neoplasms, genetic predisposition to disease, vitamin d, receptors, calcitriol, prognosis, genetic variation
7 autores
- Peter G Vaughan-Shaw🇬🇧Institute of Genetics and Cancer; University of Edinburgh
- Fiona O’Sullivan🇮🇪Trinity College Dublin
- Susan Mary Farrington🇬🇧Institute of Genetics and Cancer; University of Edinburgh
- Evropi Τheodoratou🇬🇧Glasgow Centre for Population Health; Institute of Genetics and Cancer; University of Edinburgh
- Harry Campbell🇬🇧Glasgow Centre for Population Health; Institute of Genetics and Cancer; University of Edinburgh
- Malcolm G. Dunlop🇬🇧Institute of Genetics and Cancer; University of Edinburgh
- Lina Zgaga🇮🇪 · autor de correspondenciaTrinity College Dublin
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D has been linked with improved cancer outcome. This systematic review and meta-analysis investigates the relationship between cancer outcomes and both vitamin D-related genetic variation and circulating 25-hydroxyvitamin D (25OHD) concentration.
Methods
A systematic review and meta-analysis of papers until November 2016 on PubMed, EMBASE and Web of Science pertaining to association between circulating vitamin D level, functionally relevant vitamin D receptor genetic variants and variants within vitamin D pathway genes and cancer survival or disease progression was performed.
Results
A total of 44 165 cases from 64 studies were included in meta-analyses. Higher 25OHD was associated with better overall survival (hazard ratio (HR=0.74, 95% CI: 0.66-0.82) and progression-free survival (HR=0.84, 95% CI: 0.77-0.91). The rs1544410 (BsmI) variant was associated with overall survival (HR=1.40, 95% CI: 1.05-1.75) and rs7975232 (ApaI) with progression-free survival (HR=1.29, 95% CI: 1.02-1.56). The rs2228570 (FokI) variant was associated with overall survival in lung cancer patients (HR=1.29, 95% CI: 1.0-1.57), with a suggestive association across all cancers (HR=1.26, 95% CI: 0.96-1.56).
Conclusions
Higher 25OHD concentration is associated with better cancer outcome, and the observed association of functional variants in vitamin D pathway genes with outcome supports a causal link. This analysis provides powerful background rationale to instigate clinical trials to investigate the potential beneficial effect of vitamin D in the context of stratification by genotype.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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