Docosahexaenoic acid in the treatment of rheumatoid arthritis: A double-blind, placebo-controlled, randomized cross-over study with microalgae vs. sunflower oil
Dawczynski C, Dittrich M, Neumann T, Goetze K, Welzel A, Oelzner P, Völker S, Schaible AM, Troisi F, Thomas L, Pace S, Koeberle A, Werz O, Schlattmann P, Lorkowski S, Jahreis G
Clinical nutrition (Edinburgh, Scotland) · 77 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Bundesministerium für Bildung und Forschung
- Subvenciones
- Bundesministerium für Bildung und Forschung (01EA1337A)
Según 1 financiador declarado.
Publicación
- Publicado
- 2017-03-06 · Clin Nutr · vol. 37 · número 2 · págs. 494–504
- Editorial
- Elsevier BV
- Citado
- 121 citas · más que el 93% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Rheumatoid Arthritis Research and Therapies · Systemic Lupus Erythematosus Research
- Palabras clave
- docosahexaenoic acid, rheumatoid arthritis, microalgae oil, Schizochytrium, sunflower oil, omega-3 fatty acids, arachidonic acid, thromboxane B2, 5-hydroxyeicosatetraenoic acid, maresins, DAS28
- MeSH
- humans, arthritis, rheumatoid, docosahexaenoic acids, plant oils, treatment outcome, pilot projects, cross-over studies, double-blind method, middle aged, germany, female, male, microalgae, sunflower oil
16 autores
- Christine Dawczynski🇩🇪 · autor de correspondenciaFriedrich Schiller University Jena
- Manja Dittrich🇩🇪Friedrich Schiller University Jena
- Thomas E. Neumann🇩🇪Jena University Hospital; Friedrich Schiller University Jena
- K. Goetze🇩🇪Jena University Hospital; Friedrich Schiller University Jena
- A. Welzel🇩🇪Jena University Hospital; Friedrich Schiller University Jena
- Peter Oelzner🇩🇪Jena University Hospital; Friedrich Schiller University Jena
- Susanna Völker🇩🇪Friedrich Schiller University Jena
- A.M. Schaible🇩🇪Friedrich Schiller University Jena
- Fabiana Troisi🇩🇪Friedrich Schiller University Jena
- Lisa M. Black Thomas🇩🇪Friedrich Schiller University Jena
- Simona Pace🇩🇪Friedrich Schiller University Jena
- Andreas Koeberle🇩🇪Friedrich Schiller University Jena
- Oliver Werz🇩🇪Friedrich Schiller University Jena
- Peter Schlattmann🇩🇪Jena University Hospital
- Stefan Lorkowski A🇩🇪Friedrich Schiller University Jena
- Gerhard Jahreis🇩🇪Friedrich Schiller University Jena
Resumen
El texto original del estudio, en el idioma en que se publicó.
The potential of fish or fish oil as supplier for eicosapentaenoic acid (EPA, C20:5n3) and docosahexaenoic acid (DHA, C22:6n3) for reducing cardiovascular risk factors and supporting therapy of chronic inflammatory diseases, has been investigated intensively, but our knowledge about the physiological effects of the individual compounds EPA and DHA are limited.
Study design
In this double-blind pilot study, thirty-eight patients with defined RA were allocated to consume foods enriched with microalgae oil from Schizochytrium sp. (2.1 g DHA/d) or sunflower oil (placebo) for 10 weeks (cross-over), maintaining the regular RA medication during the study.
Results
In contrast to placebo, the daily consumption of DHA led to a decline in the sum of tender and swollen joints (68/66) from 13.9 ± 7.4 to 9.9 ± 7.0 (p = 0.010), total DAS28 from 4.3 ± 1.0 to 3.9 ± 1.2 (p = 0.072), and ultrasound score (US-7) from 15.1 ± 9.5 to 12.4 ± 7.0 (p = 0.160). The consumption of placebo products caused an increase of the n-6 PUFA linoleic acid and arachidonic acid (AA) in erythrocyte lipids (EL, p 2 and the capacity of blood to convert AA to the pro-inflammatory 5-lipoxygenase product 5-hydroxyeicosatetraenoic acid were significantly reduced, while levels of the DHA-derived maresin/resolvin precursors 14-/17-hydroxydocosahexaenoic acid significantly increased due to DHA supplementation.
Conclusion
The study shows for the first time that supplemented microalgae DHA ameliorates disease activity in patients with RA along with a shift in the balance of AA- and DHA-derived lipid mediators towards an anti-inflammatory/pro-resolving state.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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