Mapping the pharmacological modulation of brain oxygen metabolism: The effects of caffeine on absolute CMRO<sub>2</sub> measured using dual calibrated fMRI
Merola A, Germuska MA, Warnert EA, Richmond L, Helme D, Khot S, Murphy K, Rogers PJ, Hall JE, Wise RG
NeuroImage · 38 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Wellcome Trust
- Gobierno
- Higher Education Funding Council for Wales
- Universidad u hospital
- Cardiff University
- Gobierno
- Engineering and Physical Sciences Research Council
- Gobierno
- UK Engineering and Physical Sciences Research Council
- Sin clasificar
- Career Development Fellowship
- Subvenciones
- Engineering and Physical Sciences Research Council (EP/K020404/1); Wellcome Trust (090199); Engineering and Physical Sciences Research Council (EP/K020404/1); Wellcome Trust (WT090199); Wellcome Trust (200804/Z/16/Z)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2017-03-18 · Neuroimage · vol. 155 · págs. 331–343
- Editorial
- Elsevier BV
- Citado
- 42 citas · más que el 94% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 71 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Advanced MRI Techniques and Applications · Coffee research and impacts · Functional Brain Connectivity Studies
- Palabras clave
- caffeine, cerebral oxygen consumption, hypercapnia, hyperoxia, cerebral blood flow, oxygen extraction fraction, cerebrovascular reactivity, forward model, drug effects on the brain
- MeSH
- humans, caffeine, central nervous system stimulants, magnetic resonance imaging, double-blind method, oxygen consumption, cerebrovascular circulation, adult, female, male, young adult, functional neuroimaging, gray matter
10 autores
- Alberto Merola🇬🇧Cardiff University
- Michael A. Germuska🇬🇧Cardiff University
- Esther A. H. Warnert🇬🇧Cardiff University
- Lewys Richmond🇬🇧Cardiff University
- Daniel Helme🇬🇧Cardiff University
- Sharmila Khot🇬🇧Cardiff University
- Kevin Murphy🇬🇧Cardiff University
- Peter J. Rogers🇬🇧University of Bristol
- Judith E. Hall🇬🇧Cardiff University
- Richard G. Wise🇬🇧 · autor de correspondenciaCardiff University
Resumen
El texto original del estudio, en el idioma en que se publicó.
This study aims to map the acute effects of caffeine ingestion on grey matter oxygen metabolism and haemodynamics with a novel MRI method. Sixteen healthy caffeine consumers (8 males, age=24.7±5.1) were recruited to this randomised, double-blind, placebo-controlled study. Each participant was scanned on two days before and after the delivery of an oral caffeine (250mg) or placebo capsule. Our measurements were obtained with a newly proposed estimation approach applied to data from a dual calibration fMRI experiment that uses hypercapnia and hyperoxia to modulate brain blood flow and oxygenation. Estimates were based on a forward model that describes analytically the contributions of cerebral blood flow (CBF) and of the measured end-tidal partial pressures of CO2 and O2 to the acquired dual-echo GRE signal. The method allows the estimation of grey matter maps of: oxygen extraction fraction (OEF), CBF, CBF-related cerebrovascular reactivity (CVR) and cerebral metabolic rate of oxygen consumption (CMRO2). Other estimates from a multi inversion time ASL acquisition (mTI-ASL), salivary samples of the caffeine concentration and behavioural measurements are also reported. We observed significant differences between caffeine and placebo on average across grey matter, with OEF showing an increase of 15.6% (SEM±4.9%, p2 showed differences of -30.4% (SEM±1.6%, p2 reductions mainly in frontal gyrus, parietal and occipital lobes. In conclusion, we propose the estimation framework based on our novel forward model with a dual calibrated fMRI experiment as a viable MRI method to map the effects of drugs on brain oxygen metabolism and haemodynamics with voxel-wise resolution.
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