The effects of omega-3 fatty acids and vitamin E co-supplementation on clinical and metabolic status in patients with Parkinson's disease: A randomized, double-blind, placebo-controlled trial
Taghizadeh M, Tamtaji OR, Dadgostar E, Daneshvar Kakhaki R, Bahmani F, Abolhassani J, Aarabi MH, Kouchaki E, Memarzadeh MR, Asemi Z
Neurochemistry international · 114 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Vice-chancellor for Research, KUMS, and Iran
Según 1 financiador declarado.
Publicación
- Publicado
- 2017-03-22 · Neurochem Int · vol. 108 · págs. 183–189
- Editorial
- Elsevier BV
- Citado
- 161 citas · más que el 98% de estudios similares · 7.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 65 trabajos
- Acceso
- De pago
- Áreas de investigación
- Parkinson's Disease Mechanisms and Treatments · Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress
- Palabras clave
- Parkinson's disease, omega-3 fatty acids, vitamin E, linseed oil, dietary supplementation, motor function, C-reactive protein, oxidative stress, antioxidant capacity, glutathione, insulin resistance, beta-cell function, insulin sensitivity, metabolic status, neuroinflammation, neuroprotection, quality of life, depression, sleep quality, fatigue, cognitive function
- MeSH
- humans, parkinson disease, vitamin e, fatty acids, omega-3, linseed oil, double-blind method, dietary supplements, aged, aged, 80 and over, middle aged, female, male
10 autores
- Mohsen Taghizadeh🇮🇷Kashan University of Medical Sciences
- Omid Reza Tamtaji🇮🇷Kashan University of Medical Sciences
- Ehsan Dadgostar🇮🇷Kashan University of Medical Sciences
- Reza Daneshvar Kakhaki🇮🇷Kashan University of Medical Sciences
- Fereshteh Bahmani🇮🇷Kashan University of Medical Sciences
- Javad Abolhassani🇮🇷Kashan University of Medical Sciences
- Mohammad Hossein Aarabi🇮🇷Kashan University of Medical Sciences
- Ebrahim Kouchaki🇮🇷Kashan University of Medical Sciences
- Mohammad Reza Memarzadeh🇮🇷University of Kashan
- Zatollah Asemi🇮🇷 · autor de correspondenciaKashan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
The current research was performed to evaluate the effects of omega-3 fatty acids and vitamin E co-supplementation on clinical signs and metabolic status in people with Parkinson's disease (PD). This randomized double-blind placebo-controlled clinical trial was conducted in 60 patients with PD. Participants were randomly assigned into two groups to receive either 1000 mg omega-3 fatty acids from flaxseed oil plus 400 IU vitamin E supplements (n = 30) or placebo (n = 30) for 12 weeks. Unified Parkinson's disease rating stage (UPDRS) were recorded at baseline and the after 3-month intervention. After 12 weeks' intervention, compared with the placebo, omega-3 fatty acids and vitamin E co-supplementation led to a significant improve in UPDRS (-3.3 ± 10.0 vs. +4.4 ± 14.9, P = 0.02). Furthermore, co-supplementation decreased high-sensitivity C-reactive protein (hs-CRP) (-0.3 ± 0.6 vs. +0.3 ± 0.3 μg/mL, P < 0.001), and increased total antioxidant capacity (TAC) (+65.2 ± 68.7 vs. +16 ± 52.4 μmol/L, P = 0.003) and glutathione (GSH) concentrations (+41.4 ± 80.6 vs. -19.6 ± 55.9 μmol/L, P = 0.001) compared with the placebo. Additionally, co-supplementation meaningfully decreased insulin (-2.1 ± 4.9 vs. +1.4 ± 6.2 μIU/mL, P = 0.01), homeostasis model of assessment-estimated insulin resistance (-0.7 ± 1.8 vs.+0.3 ± 1.6, P = 0.02) and Beta cell function (-5.9 ± 13.9 vs. +5.7 ± 25.5, P = 0.03), and increased quantitative insulin sensitivity check index (+0.009 ± 0.02 vs. -0.006 ± 0.03, P = 0.03) compared with the placebo. Overall, our study demonstrated that omega-3 fatty acids and vitamin E co-supplementation in people with PD had favorable effects on UPDRS, hs-CRP, TAC, GSH and markers of insulin metabolism.
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