Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults
Lalia AZ, Dasari S, Robinson MM, Abid H, Morse DM, Klaus KA, Lanza IR
Aging · 128 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Mayo Clinic
- Universidad u hospital
- Mayo Foundation for Medical Education and Research
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCATS NIH HHS
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Center for Advancing Translational Sciences (UL1-TR000135); National Institute of Diabetes and Digestive and Kidney Diseases (U24 DK100469); National Center for Advancing Translational Sciences (KL2 TR-000136); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK084567)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-04-05 · Aging (Albany NY) · vol. 9 · número 4 · págs. 1096–1129
- Editorial
- Impact Journals LLC
- Citado
- 168 citas · más que el 98% de estudios similares · 6.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 72 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Adipose Tissue and Metabolism
- Palabras clave
- Polyunsaturated fatty acid, Bioenergetics, Sarcopenia, Internal medicine, Anabolism, Endocrinology, Mitochondrion, Oxidative phosphorylation, Respirometry, Respiration, Metabolism, Context (archaeology), Biology, Medicine, Biochemistry, Fatty acid, Anatomy
- MeSH
- muscle, skeletal, sarcoplasmic reticulum, mitochondria, muscle, humans, reactive oxygen species, fatty acids, omega-3, muscle proteins, oxidants, exercise, energy metabolism, oxygen consumption, anaerobic threshold, aging, adolescent, adult, aged, aged, 80 and over, female, male, young adult
7 autores
- Antigoni Z. Lalia🇺🇸Mayo Clinic
- Surendra Dasari🇺🇸Mayo Clinic
- Matthew M. Robinson🇺🇸Mayo Clinic
- Hinnah Abid🇺🇸Mayo Clinic
- Dawn M. Morse🇺🇸Mayo Clinic
- Katherine A. Klaus🇺🇸Mayo Clinic
- Ian R. Lanza🇺🇸 · autor de correspondenciaMayo Clinic
Resumen
El texto original del estudio, en el idioma en que se publicó.
Omega-3 polyunsaturated fatty acids (n3-PUFA) are recognized for their anti-inflammatory effects and may be beneficial in the context of sarcopenia. We determined the influence of n3-PUFA on muscle mitochondrial physiology and protein metabolism in older adults. Twelve young (18-35 years) and older (65-85 years) men and women were studied at baseline. Older adults were studied again following n3-PUFA supplementation (3.9g/day, 16 weeks). Muscle biopsies were used to evaluate respiratory capacity (high resolution respirometry) and oxidant emissions (spectrofluorometry) in isolated mitochondria. Maximal respiration was significantly lower in older compared to young. n3-PUFA did not change respiration, but significantly reduced oxidant emissions. Participants performed a single bout of resistance exercise, followed by biopsies at 15 and 18 hours post exercise. Several genes involved in muscle protein turnover were significantly altered in older adults at baseline and following exercise, yet muscle protein synthesis was similar between age groups under both conditions. Following n3-PUFA supplementation, mixed muscle, mitochondrial, and sarcoplasmic protein synthesis rates were increased in older adults before exercise. n3-PUFA increased post-exercise mitochondrial and myofibrillar protein synthesis in older adults. These results demonstrate that n3-PUFA reduce mitochondrial oxidant emissions, increase postabsorptive muscle protein synthesis, and enhance anabolic responses to exercise in older adults.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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