A pilot interventional study to evaluate the impact of cholecalciferol treatment on HbA1c in type 1 diabetes (T1D)
Perchard R, Magee L, Whatmore A, Ivison F, Murray P, Stevens A, Mughal MZ, Ehtisham S, Campbell J, Ainsworth S, Marshall M, Bone M, Doughty I, Clayton PE
Endocrine connections · 10 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- National Institute for Health and Care Research (CL-2012-06-005)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-04-05 · Endocr Connect · vol. 6 · número 4 · págs. 225–231
- Editorial
- Bioscientifica
- Citado
- 20 citas · más que el 83% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Diabetes and associated disorders · Vitamin D Research Studies · Diabetes Management and Research
- Palabras clave
- Medicine, Cholecalciferol, Vitamin D and neurology, vitamin D deficiency, Internal medicine, Cohort, Vitamin, Diabetes mellitus, Type 2 diabetes, Gastroenterology, Pediatrics, Endocrinology
14 autores
- Reena Perchard🇬🇧University of Manchester
- Lucia Magee🇬🇧University of Manchester
- Andrew James Whatmore🇬🇧University of Manchester
- Fiona Ivison🇬🇧Manchester University NHS Foundation Trust
- Philip George Murray🇬🇧University of Manchester; Royal Manchester Children's Hospital
- Adam Stevens🇬🇧University of Manchester
- Mohammed Zulf Mughal🇬🇧Royal Manchester Children's Hospital
- Sarah Ehtisham🇬🇧Royal Manchester Children's Hospital
- Julie Campbell🇬🇧Royal Manchester Children's Hospital
- SUSAN AINSWORTH🇬🇧Royal Manchester Children's Hospital
- Michael Marshall🇬🇧Manchester University NHS Foundation Trust
- M Bone🇬🇧Royal Manchester Children's Hospital
- Ian Doughty🇬🇧Royal Manchester Children's Hospital
- Peter Clayton🇬🇧 · autor de correspondenciaUniversity of Manchester; Royal Manchester Children's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Higher 25(OH)D3 levels are associated with lower HbA1c, but there are limited UK interventional trials assessing the effect of cholecalciferol on HbA1c.
Aims
(1) To assess the baseline 25(OH)D3 status in a Manchester cohort of children with type 1 diabetes (T1D). (2) To determine the effect of cholecalciferol administration on HbA1c.
Methods
Children with T1D attending routine clinic appointments over three months in late winter/early spring had blood samples taken with consent. Participants with a 25(OH)D3 level 10 years) units. HbA1c levels before and after treatment were recorded.
Results
Vitamin D levels were obtained from 51 children. 35 were Caucasian, 11 South Asian and 5 from other ethnic groups. 42 were vitamin D deficient, but 2 were excluded from the analysis. All South Asian children were vitamin D deficient, with mean 25(OH)D3 of 28 nmol/L. In Caucasians, there was a negative relationship between baseline 25(OH)D3 level and HbA1c (r = -0.484, P t = 1.010, P = 0.328) or at 1 year (t = -1.173, P = 0.248) before and after treatment. One-way ANCOVA, controlling for age, gender, ethnicity, BMI and diabetes duration showed no difference in Δ HbA1c level.
Conclusion
We report important findings at baseline, but in children treated with a stat dose of cholecalciferol, there was no effect on HbA1c. Further studies with larger sample sizes and using maintenance therapy are required.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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