The effect of low-level laser therapy as an adjunct to non-surgical periodontal treatment on gingival crevicular fluid levels of transforming growth factor-beta 1, tissue plasminogen activator and plasminogen activator inhibitor 1 in smoking and non-smoking chronic periodontitis patients: A split-mouth, randomized control study
Pamuk F, Lütfioğlu M, Aydoğdu A, Koyuncuoglu CZ, Cifcibasi E, Badur OS
Journal of periodontal research · 23 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Bilimsel Araştirma Projeleri Birimi, Istanbul Üniversitesi
- Subvenciones
- Bilimsel Araştirma Projeleri Birimi, Istanbul Üniversitesi (480.2‐2401)
Según 1 financiador declarado.
Publicación
- Publicado
- 2017-04-10 · J Periodontal Res · vol. 52 · número 5 · págs. 872–882
- Editorial
- Wiley
- Citado
- 45 citas · más que el 95% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 58 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Oral microbiology and periodontitis research · Periodontal Regeneration and Treatments
- Palabras clave
- low-level laser therapy, chronic periodontitis, scaling and root planing, smoking, gingival crevicular fluid, TGF-β1, tissue plasminogen activator, plasminogen activator inhibitor-1, adjunctive periodontal therapy, periodontal inflammation biomarkers, periodontal parameters, gingival recession
- MeSH
- gingival crevicular fluid, humans, periodontal pocket, tissue plasminogen activator, plasminogen activator inhibitor 1, dental plaque index, periodontal index, dental scaling, root planing, smoking, wound healing, time factors, adult, transforming growth factor beta1, laser therapy, chronic periodontitis, low-level light therapy
6 autores
- Ferda Pamuk🇹🇷Yeditepe University; Istanbul Aydın University
- Müge Lütfioğlu🇹🇷 · autor de correspondenciaOndokuz Mayıs University
- Ahmet Aydoğdu🇹🇷Başkent University
- Cenker Zeki Koyuncuoğlu🇹🇷Istanbul Aydın University
- E. Cifcibasi🇹🇷Istanbul University-Cerrahpaşa; Istanbul University
- Osman Badur🇹🇷Istanbul University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objective
This study aimed to investigate the effects of low-level laser therapy (LLLT) as an adjunct to scaling and root planing (SRP) on smoking and non-smoking patients with chronic periodontitis.
Material and methods
The study was conducted using a split-mouth design with 30 patients with chronic periodontitis (15 smokers, 15 non-smokers) and 30 healthy individuals matched for age, sex and smoking status as controls. Groups were constituted as follows: Cp+SRP+Sham: non-smokers with chronic periodontitis treated with SRP; Cp+SRP+LLLT: non-smokers with chronic periodontitis treated with SRP+LLLT; SCp+SRP+Sham: smokers with chronic periodontitis treated with SRP; SCp+SRP+LLLT: smokers with chronic periodontitis treated with SRP+LLLT; C: control group comprised of periodontally healthy non-smokers; SC: control group comprised of periodontally healthy smokers. LLLT was first applied on the same day as SRP and again on days 2 and 7 after SRP treatment. Clinical parameters were recorded before non-surgical periodontal treatment (baseline) and on day 30. Gingival crevicular fluid samples were collected before periodontal treatment (baseline) and during follow-up visits on days 7, 14 and 30. Gingival crevicular fluid transforming growth factor (TGF)-β1, tissue plasminogen activator (tPA) and plasminogen activator inhibitor 1 (PAI-1) levels were measured using enzyme-linked immunosorbent assay.
Results
All clinical parameters showed significant reductions between baseline and day 30 following SRP treatment in both the LLLT and sham groups (P.05). Gingival crevicular fluid PAI-1 levels decreased significantly in the SCp+SRP+sham and SCp+SRP+LLLT groups (P.05) at any of the time points measured, both LLLT groups showed significant reductions in tPA/PAI-1 ratios over time.
Conclusion
Within the limits of this study, LLLT may be understood to play a role in the modulation of periodontal tissue tPA and PAI-1 gingival crevicular fluid levels, particularly in smoking patients with chronic periodontitis, and may thus be recommended as an adjunct to non-surgical periodontal treatment.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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