25-Hydroxyvitamin D serum level in Hashimoto's thyroiditis, but not Graves' disease is relatively deficient
Ke W, Sun T, Zhang Y, He L, Wu Q, Liu J, Zha B
Endocrine journal · 45 citas
Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Natural Science Foundation of Shanghai
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (81302570)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2017-01-01 · Endocr J · vol. 64 · número 6 · págs. 581–587
- Editorial
- Japan Endocrine Society
- Citado
- 65 citas · más que el 94% de estudios similares · 3.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 28 trabajos
- Acceso
- Acceso abierto (publicación gratuita)
- Áreas de investigación
- Vitamin D Research Studies · Thyroid Disorders and Treatments · Adrenal Hormones and Disorders
- Palabras clave
- Medicine, Euthyroid, Internal medicine, Vitamin D and neurology, Endocrinology, vitamin D deficiency, Thyroiditis, Graves' disease, Thyroid function, Thyroid, Outpatient clinic
- MeSH
- thyroid gland, humans, vitamin d deficiency, hypothyroidism, calcifediol, hormone replacement therapy, severity of illness index, prevalence, risk factors, case-control studies, autoimmunity, nutritional status, adult, middle aged, china, female, graves disease, male, hashimoto disease
7 autores
- Wencai Ke🇨🇳Fudan University
- Tiange Sun🇨🇳Fudan University
- Yanan Zhang🇨🇳Fudan University
- Leqi He🇨🇳Fudan University
- Qiang En Wu🇨🇳Fudan University
- Jun Hong Liu🇨🇳Fudan University
- Bingbing Zha🇨🇳Fudan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Vitamin D is a modulator of both the innate and adaptive immune system. As vitamin D deficiency was a risk factor for some autoimmune diseases, we aimed to evaluate the serum vitamin D levels in autoimmune thyroid diseases (AITD) including Graves' disease (GD) and Hashimoto's thyroiditis (HT) and investigated the association between serum vitamin D levels and AITD. 175 AITD patients including 51 GD, 61 euthyroid HT (mild HT), 63 euthyroid HT patients with hypothyroidism receiving hormone therapy (treated HT) were recruited from the outpatient department. 51 controls were from the physical checkup center of the hospital. 25-Hydroxyvitamin D levels, thyroid function, antithyroid antibodies, IL-4, IL-17, and TNF-α were determined. Compared with the controls, treated and mild HT patients had significantly lower 25(OH)D levels (45.77±3.48 vs. 83.49±6.24 nmol/L, p<0.001) and (55.25±3.88 vs. 83.49±6.24 nmol/L, p<0.001), respectively. However, GD patients had similar 25(OH)D levels (81.77±5.60 vs. 83.49±6.24 nmol/L, p=0.808). Compared to 24.1% controls with prevalent vitamin D deficiency, mild HT and treated HT patients were significantly different (55.4%, p<0.001) and (70.3%, p<0.001), respectively; no difference was seen in the GD patients (22.9%, p=0.797). Serum 25(OH)D levels were not associated with thyroid function, antithyroid antibodies, and serum cytokines IL-4, IL-17, and TNF-α in patients with AITD. We observed relatively low vitamin D level in mild and treated HT patients, while GD patients had similar 25(OH)D levels to those of healthy individuals. Further studies are imperative to explore the complex etiology of vitamin D deficiency in AITD.
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