The serum 25-hydroxyvitamin D levels and hip fracture risk: a meta-analysis of prospective cohort studies
Lv QB, Gao X, Liu X, Shao ZX, Xu QH, Tang L, Chi YL, Wu AM
Oncotarget · 30 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Science and Technology Plan Project of Wenzhou, China
- Subvenciones
- National Natural Science Foundation of China (81501933); National Natural Science Foundation of China (Y20160369); National Natural Science Foundation of China (81372014)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2017-03-17 · Oncotarget · vol. 8 · número 24 · págs. 39849–39858
- Editorial
- Impact Journals LLC
- Citado
- 48 citas · más que el 61% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Vitamin K Research Studies
- Palabras clave
- Medicine, Hip fracture, Prospective cohort study, Relative risk, Internal medicine, Meta-analysis, Confidence interval, Cohort study, Vitamin D and neurology, Risk factor, Gastroenterology, Osteoporosis
- MeSH
- humans, hip fractures, vitamin d, prevalence, risk factors, prospective studies
8 autores
- Qingbo Lv🇨🇳Wenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Xiang Gao🇨🇳Wenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Xiang Liu🇨🇳Wenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Zhenxuan Shao🇨🇳Wenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Qianhui Xu🇨🇳Wenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Li Tang🇨🇳Wenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Yong-Long Chi🇨🇳Wenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Aimin Wu🇨🇳Wenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Hip fracture has increasingly become a social and economic burden. The relationship between serum 25-hydroxyvitamin D levels and the risk of hip fracture reported by previous studies remains controversial. We searched Pubmed and Embase to identify studies reporting the relationship between serum 25-hydroxyvitamin D levels and risk of hip fracture. Fifteen prospective cohort studies with a total of 51239 participants and 3386 hip fracture cases were included. By pooling the Relative Risk of the lowest vs. the highest categories indicated that lower levels of serum 25-hydroxyvitamin D were more likely to be a risk factor for hip fracture with adjusted Relative Risk (95%Confidence Interval) of 1.58 (1.41, 1.77). Subgroup meta-analysis examining the stability of the primary results achieved the same results. A dose-response meta-analysis showed that the risk of hip fracture was a descending curve below the line of RR=1. The descending trend was obvious when serum 25-hydroxyvitamin D levels were less than 60 nmol/L and was flat when serum 25-hydroxyvitamin D levels were more than 60 nmol/L. We found that individuals with low levels of serum 25-hydroxyvitamin D have an increased risk of hip fracture, and this effect was evident when the serum 25-hydroxyvitamin D levels were less than 60 nmol/L.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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