Randomized Controlled Trial of High-Volume Energy Drink Versus Caffeine Consumption on ECG and Hemodynamic Parameters
Fletcher EA, Lacey CS, Aaron M, Kolasa M, Occiano A, Shah SA
Journal of the American Heart Association · 53 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Defense
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-04-26 · J Am Heart Assoc · vol. 6 · número 5
- Editorial
- Wiley
- Citado
- 97 citas · más que el 97% de estudios similares · 6.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Coffee research and impacts · Cannabis and Cannabinoid Research · Pharmacology and Obesity Treatment
- Palabras clave
- Medicine, Caffeine, Blood pressure, Crossover study, Heart rate, Diastole, Cardiology, QT interval, Anesthesia, Hemodynamics, Internal medicine, Placebo
- MeSH
- heart conduction system, humans, caffeine, central nervous system stimulants, electrocardiography, risk assessment, cross-over studies, double-blind method, predictive value of tests, blood pressure, heart rate, time factors, adolescent, adult, female, male, arrhythmias, cardiac, hemodynamics, young adult, energy drinks
6 autores
- Emily A. Fletcher🇺🇸Grant Medical Center
- Carolyn S. Lacey🇺🇸Grant Medical Center
- Melenie Aaron🇺🇸Grant Medical Center
- Mark W. Kolasa🇺🇸Grant Medical Center
- Andrew Occiano🇺🇸University of the Pacific
- Sachin A. Shah🇺🇸University of the Pacific; Grant Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Caffeine in doses <400 mg is typically not considered arrhythmogenic, but little is known about the additional ingredients in energy drinks. We evaluated the ECG and blood pressure (BP) effects of high-volume energy drink consumption compared with caffeine alone.
Methods and results
This was a randomized, double-blind, controlled, crossover study in 18 young, healthy volunteers. Participants consumed either 946 mL (32 ounces) of energy drink or caffeinated control drink, both of which contained 320 mg of caffeine, separated by a 6-day washout period. ECG, peripheral BP, and central BP measurements were obtained at baseline and 1, 2, 4, 6, and 24 hours post study drink consumption. The time-matched, baseline-adjusted changes were compared. The change in corrected QT interval from baseline in the energy drink arm was significantly higher than the caffeine arm at 2 hours (0.44±18.4 ms versus -10.4±14.8 ms, respectively; P=0.02). The QTc changes were not different at other time points. While both the energy drink and caffeine arms raised systolic BP in a similar fashion initially, the systolic BP was significantly higher at 6 hours when compared with the caffeine arm (4.72±4.67 mm Hg versus 0.83±6.09 mm Hg, respectively; P=0.01). Heart rate, diastolic BP, central systolic BP, and central diastolic BP showed no evidence of a difference between groups at any time point. Post energy drink, augmentation index was lower at 6 hours.
Conclusions
The corrected QT interval and systolic BP were significantly higher post high-volume energy drink consumption when compared with caffeine alone. Larger clinical trials validating these findings and evaluation of noncaffeine ingredients within energy drinks are warranted.
Clinical trial registration
URL: http://www.clinicaltrials.gov. Unique identifier: NCT02023723.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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